A group from Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, China, etc. has reported about changes in IgG glycosylation of primary Sjögren’s syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961092/
Primary Sjögren’s syndrome (PSS) is a systemic autoimmune disease resulting in significant loss of systemic gland secretory function.
Total of 128 serum samples were used for lectin microarray analysis, obtained from 40 PSS patients), 50 primary biliary cholangitis (PBC) patients, and 38 healthy controls who were healthy volunteers.
As a result, it was found that changes in serum IgG glycosylation in PSS increased binding levels of LCA lectin compared to healthy controls and PBC patients.
