A group from Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan, etc. has reported about diagnostic biomarkers for advanced colorectal cancer (CRC).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948623/
O-glycoproteins in serum samples collected from CRC patients were enriched by using lectin affinity purification using MPL, Jacalin, and SNL, as biomarker candidates, and analyzed by LC-MS/MS in detail.
It was found that the followings can have high diagnostic efficacy to strategically predict advanced CRC groups.
- fibulin-2 (FBLN2) /T antigen
- macrophage colony-stimulating factor 1 (CSF1)/(T + di-Sialyl T)
- macrophage mannose receptor 1 (MRC1) /T
- fibrinogen alpha chain (FGA)/Sialyl T
- complement component C7 (C7) /di-Sialyl T