5 kinds of diagnostic O-glycoprotein biomarkers for advanced colorectal cancer

A group from Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan, etc. has reported about diagnostic biomarkers for advanced colorectal cancer (CRC).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948623/

O-glycoproteins in serum samples collected from CRC patients were enriched by using lectin affinity purification using MPL, Jacalin, and SNL, as biomarker candidates, and analyzed by LC-MS/MS in detail.

It was found that the followings can have high diagnostic efficacy to strategically predict advanced CRC groups.

  • fibulin-2 (FBLN2) /T antigen
  • macrophage colony-stimulating factor 1 (CSF1)/(T + di-Sialyl T)
  • macrophage mannose receptor 1 (MRC1) /T
  • fibrinogen alpha chain (FGA)/Sialyl T
  • complement component C7 (C7) /di-Sialyl T