Burkholderia oklahomensis agglutinin (BOA) lectin effectively inhibits various variants of concern of SARS-CoV-2

A group from Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh PA, USA, etc. has reported about Burkholderia oklahomensis agglutinin (BOA) lectin which could effectively inhibit SARS-CoV-2 infection.

It was shown that BOA lectin could effectively inhibit various variants of concern (VOC) of SARS-CoV-2 as shown below (EC50 for VOCs of SARS-CoV-2).

It is known that VOCs of SARS-CoV-2 possess minimal changes with respect glycosylation. Probably with this reason and since BOA binds glycans on multiple Spike proteins, possibly crosslinking different Spike proteins on a single virion or crosslinking Spike proteins on different virions, BOA lectin could inhibit various VOCs of SARS-CoV-2 infection effectively.

Actually, BOA contains two domains and therefore four glycan binding sites, and makes interviron and intraviron crosslinkings as show below.