Burkholderia oklahomensis agglutinin (BOA) lectin effectively inhibits various variants of concern of SARS-CoV-2

Burkholderia oklahomensis agglutinin (BOA) lectin effectively inhibits various variants of concern of SARS-CoV-2

A group from Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh PA, USA, etc. has reported about Burkholderia oklahomensis agglutinin (BOA) lectin which could effectively inhibit SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810211/

It was shown that BOA lectin could effectively inhibit various variants of concern (VOC) of SARS-CoV-2 as shown below (EC50 for VOCs of SARS-CoV-2).

It is known that VOCs of SARS-CoV-2 possess minimal changes with respect glycosylation. Probably with this reason and since BOA binds glycans on multiple Spike proteins, possibly crosslinking different Spike proteins on a single virion or crosslinking Spike proteins on different virions, BOA lectin could inhibit various VOCs of SARS-CoV-2 infection effectively.

Actually, BOA contains two domains and therefore four glycan binding sites, and makes interviron and intraviron crosslinkings as show below.

Mx

Pioneer in Glycan Profiling Technology Environmentally Regenerative Agriculture

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