Roles of ΔH69/V70 mutation seen in multiple independent lineages of SARS-CoV-2 

Roles of ΔH69/V70 mutation seen in multiple independent lineages of SARS-CoV-2 

A group from University of Cambridge, UK, etc. has reported on roles of ΔH69/V70 mutation seen in multiple independent lineages of SARS-CoV-2.
https://pubmed.ncbi.nlm.nih.gov/34166617/

There was no overall change in susceptibility to serum neutralization for ΔH69/V70 relative to the WT, suggesting that ΔH69/V70 does not represent an important antibody escape mechanism.

Western blotting for S2 spike indicated a higher amount of cleaved spike in ΔH69/V70 bearing virions and in the HEK293T producer cell lysates. 

As a conclusion, it was found that ΔH69/V70 itself is not an antibody evasion mechanism, but increases infectivity associated with enhanced incorporation of cleaved spike into virions.
 

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