A group from Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China has reported about changes in IgG glycosylation patterns for antiphospholipid syndrome (APS) patients with lectin microarray.
https://onlinelibrary.wiley.com/doi/10.1111/sji.13366
It was found that IgG complexes from APS patients exhibited a significantly elevated exposure of GalNAc residues compared with healthy controls and disease controls. This suggests that elevated GalNAc on IgG plays a role in the progression of APS. However, compared with N-linked glycosylation, the effects of O-glycosylation on IgG structure and function remain to be elucidated.
