A group from College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China, etc, has reported about changes in glycan patterns and glycan-related genes in the medial prefrontal cortex of autism spectrum disorders (ASD) rats.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772556/
With using lectin microarrays, the following changes in glycosylation were found in ASD rats.
(1) Branched high-mannose (recognized by ConA) was upregurated in ASD rats,
(2) complex-type antennary agalacto N-glycan (recognized by GSL-II and PHA-E) was up-regulated in ASD rats, and
(3) Siaα2-3 Gal/GalNAc (recognized by WGA and MAL-I) and terminal GalNAc structure (recognized by BPL and VVA) were down-regulated in ASD rats.
