A group from Georgia State University, etc. has reported N-glycan binding specificity of siglecs using glycan arrays.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116747/
Siglec-3, -9, and -10 prefer the α1-3 branching structure when Siaα2-6Galβ1-4GlcNAc terminal epitope serves as the binding ligand but prefer the opposite α1-6 branching structure when Siaα2-3Galβ1-4GlcNAc epitope serves as the ligand. Interestingly, Siglec-10 exhibited strong affinity to Neu5Gc-containing N-glycans
