A group from Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, etc. has reported that FIB-4 would be a good independent predictor of COVID-19 mortality.
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep4.1650
A total of 202 participants were selected from the two cohorts (n = 87 from the MassCPR cohort and n = 115 from the BWH cohort).
FIB-4 is defined by the following formula:
FIB-4=(Age(year)xAST(U/L)/(PLT(100/uL)x√ALT(U/L))
In logistic regression analysis, higher FIB-4 was associated with mortality and an unadjusted OR = 1.75 (95% CI, 1.37, 2.23; P < 0.001), and after adjusting for sex, BMI, ethnicity, hypertension, diabetes, remdesivir use, and liver diseases, FIB-4 remained to be associated with mortality (adjusted OR = 1.79; 95% CI, 1.36, 2.35; P < 0.001)
In conclusion, it was shown that FIB-4 at admission would be a good independent index in predicting COVID-19 death, with an AUC of 0.79.
