Changes in glycan modification accompanied by change from ESC to epiblast-like cells (EpiLCs) and its control factor behind them

Changes in glycan modification accompanied by change from ESC to epiblast-like cells (EpiLCs) and its control factor behind them

A group from Soka University etc. has reported on changes in glycan modification accompanied by change from ESC to epiblast-like cells (EpiLCs) and a control factor behind them.
https://www.nature.com/articles/s41598-020-79666-4

With the change from ESC to EpiLCs, the following changes in glycan modification occur:

  1. For N-type glycans, the high mannose structure is the main structure in common, but in EpiLCs, fucose modification, bisecting, and Sia modification are increased, for Sia, α2-6 is the main linkage, and typeI LacNAc (Galβ1-3GlcNAc) is highly expressed with α1-2Fuc modified.
  2. For O-type sugar chains, Tn antigen and O-GlcNAc are the main in common, but in EpiLCs, the expression of O-glycan is generally increasing, and elongated mucin type O-glycans also increase.
  3. For Glycosaminoglycans (GAG), EpiLCs generally increase GAG expression, especially Heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).
  4. For glycolipids, EpiLCs cause structural changes from globo (Gb) to ganglio (Gg).

Behind these glycan modification, polycomb repressive complex 2 (PRC2), a chromatin protein, was shown to be involved as a regulator. A number of glycosyltransferase genes involved in glycan modification of ESC is under the control of PRC2.

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