A group from Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand has reported about a new lectin ALA extracted from the seeds of Artocarpus lakoocha.
https://www.nature.com/articles/s41598-024-84444-7
ALA exhibits agglutinin activity and has binding specificity to T- and Tn-associated glycoproteins and monosaccharides such as Gal and GalNAc.
It was confirmed that glycans identified by ALA were elevated in human Cholangiocarcinoma (CCA) tissues.
ALA significantly reduced cell viability of CCA cells, KKU-100 and KKU-213B, in a dose-dependent manner (up to 30 µg/mL) with approximately a 30% decrease observed at the highest concentration. And also, ALA significantly reduced the migration and invasion ability of KKU-100 and KKU-213B cells in a dose-dependent manner with 1–2 µg/mL which did not affect cell viability.
These results suggest their therapeutic potential effects on CCA treatments.