Glycan markers for pancreatic duct adenocarcinoma

Glycan markers for pancreatic duct adenocarcinoma

A group from Medical University of South Carolina etc. has reported their findings on glycan markers for pancreatic duct adenocarcinoma.

In order to study the glycan markers of pancreatic duct adenocarcinoma in detail, MS (MALDI-FTICR, MALDI-QTOF), antibody immunostaining (CA19-9, TRA-1-60), lectin staining (PHA-E, GSL-II) were used.

To summarize the results, pancreatic duct adenocarcinoma has an increase in the structure of α2-3 Sia, poly-LacNAc, branching, bisecting GlcNAc, core fucose, and terminal GalNAc compared to normal tissues. As for Sia, α2-3Sia is mainly expressed in tumor stroma regions, and α2-6Sia is slightly stronger in adenocarcinoma regions.

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