A group from Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, The Netherlands, etc. has identified a novel pathway activated by SARS-CoV-2 that suppresses TLR4, the major bacterial TLR on human dendritic cells (DCs).
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011735
It was strongly suggested that SARS-CoV-2 interacts with the C-type lectin receptor DC-SIGN leading to Raf-1-mediated suppression of TLR4 signaling. As a result, SARS-CoV-2 actively suppresses DC function via DC-SIGN, and causes the higher mortality rates observed in patients with COVID-19 and bacterial superinfections.