SARS-CoV-2 specific antibody transfer to breastmilk is dominated by IgA and IgM

SARS-CoV-2 specific antibody transfer to breastmilk is dominated by IgA and IgM

A group from Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA, etc. has reported that SARS-CoV-2 specific antibody transfer to breastmilk is dominated by IgA and IgM.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531199/

Previous studies clearly illustrated the evolution and transfer of Fc-effector function in pregnant women via placenta to their infants, but less is known about the transfer of Fc-effector function across breastmilk.

As expected, mothers infected with SARS-CoV-2 possessed SARS-CoV-2-specific antibodies in serum and breastmilk that were not present in SARS-CoV-2-uninfected specimens. But, interestingly, robust transfer of IgA and IgM was observed in breastmilk, but the transfer of IgG1 was more limited as shown below.

Mx

Pioneer in Glycan Profiling Technology Environmentally Regenerative Agriculture

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