Gal modification of laminin receptor integrin α6β1 is reduced in hepatocellular carcinoma, and thereby accelerates cancer cell invasion

A group from Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan, etc. has reported that Beta1,4-galactosyltransferases (B4GALTs) downregulation upregurates agalacto N-glycans and enhances the laminin-binding activity of integrin α6 and integrin β1 to promote invasiveness of Hepatocellular carcinoma (HCC) cells.