A group from Columbia University Vagelos College of Physicans and Surgeons etc. has reported on the efficacy of Moderna and Pfizer vaccines for the new coronavirus (SARS-CoV-2) variants in the UK and South Africa.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852271/
In addition to the existing D614G mutation, UK and South African variants contain the following mutations: there are 8 mutations in UK variants (B.1.1.7) (abbreviated as UKΔ8), and 9 mutations in South African variants (B.1.351) (abbreviated as SAΔ9).
Neutralization titers were measured by using serum samples from volunteers vaccinated with Moderna and Pfizer referring D614G as WT. The mean loss of neutralizing activity against UKΔ8 appeared to be small (1.8 fold, Moderna; 2.0 fold, Pfizer), but was quite significant against SAΔ9 (8.6 fold, Moderna; 6.5 fold, Pfizer) .
