Diagnosis of Hepatocellular carcinoma (HCC) with using AFP and changes in IgG/IgM glycosylation

A group from Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China, etc. has reported about diagnosis of Hepatocellular carcinoma (HCC) with using Lectin Microarrays.

A model combining changes in IgG glycosylaion detected by three lectins (EEL, MPL, and TC) and Alpha-fetoprotein (AFP) showed good diagnostic accuracy for HCC, an area under the ROC curve of 0.96 (P < 0.05), the sensitivity of 82.54%, and the specificity of 100%.

Another model combining changes in IgM glycosylaion detected by one lectin (DSL) and AFP showed an area under the curve of 0.90 (P < 0.05), sensitivity of 75.41%, and specificity of 100%.