Detecting Triple-Negative Breast Cancer with using Glycan Profiling of Extracellular Vesicles

A group from Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, China, etc. has reported about glycan profiling of extracellular vesicles (EVs) for detecting triple-negative breast cancer (TNBC).

A panel of 3 lectins (ConA, WGA and RCA I) was used to detect the EV surface glycan profiles unique to TNBC.
As a result, they succeeded in getting an area under ROC curve (AUC) of 0.91 with using the weighted sum of 3 lectins (ConA, WGA and RCA I) for discriminatiing TNBC from other BCs and HDs.