Changes in glycosylation of B cells and T cells in systemic lupus erythematosus patients

A group from Departamento de Medicina y Zootecnia de Cerdos, Universidad Nacional Autónoma de México, Ciudad de México, Mexico, etc. has reported about changes in glycosylation of B cells and T cells in systemic lupus erythematosus (SLE) patients.

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect every organ and system in the body.

In the case of B cells, glycosylation studies have been directed primarily at immunoglobulins. SLE patients have alterations in the glycosylation of immunoglobulin G. A greater recognition of the AAL lectin, which has an affinity for fucosylated residues, has been observed in comparison with healthy individuals. Increased recognition of the LCA lectin, which is specific for the core fucosylated trimannose N-glycan, towards immunoglobulin G has been also reported in SLE patients. Using ultra-resolution liquid chromatography, it was also found that they present a decrease in IgG galactosylation and sialylation.

It has been shown that T cells from SLE patients present alterations in O-glycosylation using the ALL lectin, which recognizes core 1 in coactivating T cell receptors. T cells from patients with active SLE had less recognition by ALL than those with inactive SLE, and expression of receptors recognized by ALL was inversely correlated with disease activity. Another study reported increased expression of Tn antigen-type O-glycans in T cells from SLE patients using VVA lectin.

A decrease in O-GlcNAcylation and phosphorylation of E74-like factor 1 (ELF-1) has been observed in SLE patients.