A group from Jackson State University, USA, etc. has reported anti-spike antibody attached gold nanoparticles (GNPs) have the capability to inhibit SARS-CoV-2 infection perfectly.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323809/
Citrate coated original size of GNPs was 15 ± 2 nm, and the size of GNPs increased to ∼27 ± 6 nm by conjugating antibodies.
Pseudo SARS-CoV-2 (# C1110G, Montana Molecular, Bozeman, MT) was used as the model virus, and HEK293T cells were used as host cells, which express ACE2 known as infection receptor of SARS-CoV-2.
As shown below, anti-spike antibody attached gold nanoparticles block viral replication and virus spread in HEK293T cells. It was found that the inhibition efficiency was 100% for 100 ng/mL anti-spike antibody attached gold nanoparticles and 60% for 10 ng/mL anti-spike antibody attached GNPs. In contrast, our experimental data indicate that the inhibition efficiencies for PEG coated GNPs and 100 ng mL−1 antibody only were less than 1%.
< a href="https://www.emukk.com/WP/wp-content/uploads/2021/08/GNPantibody_SARS-CoV-2.png">
However, blog admin does not know if this method could be used in vivo.