Aberrant serum protein N-glycome patterns with endometrial cancer

A group from Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, etc. has reported about aberrant serum protein N-glycome patterns with endometrial cancer (EC).

In this paper, serum N-glycome patterns of endometrial cancer (EC) were investigated using MALDI-TOF-MS to identify candidate biomarkers.

As a result, the following changes in glycosylation were identified.
(1) The ratio of high-mannose to hybrid glycans increased greatly in EC compared with controls.
(2) The fucosylation decreased significantly in EC.
(3) The sialylation in bi-antennary and tri-antennary glycans increased significantly in EC than in controls, mainly due to the increase of α2,6-linked glycan species.