A group from Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Brazil, etc. has reported about immune-enhancing activity of polysaccharides from wild mushroom (Gymnopilus imperialis).
In this study, the aqueous extract was obtained from dried basidiomata of G. imperialis, which was fractioned by several steps yielding three main polysaccharide fractions (Gi-MRSW, Gi-FSME, and Gi-FPME) as shown below.
Among those polysaccharides, only the Gi-MRSW fraction displayed immune-enhancing activity on murine macrophages similar to LPS. The detailed molecular structure was not mentioned here.