There is a noteworthy paper on the origin of the novel coronavirus (SARS-CoV-2).
https://zenodo.org/record/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0QudcBRHZ0dnPPCZNz8Yg2oGfleP1_ZxoipzEI
The central points of the discussion are:
RaTG13 (96.2%) hosted by horseshoe bat and MP789 (90.1%) hosted by pangolin are close to SARS-CoV-2.
But,
- Syn/non-syn ratio of spontaneous gene mutations must not fluctuate significantly across the entire region of the S protein, whereas SARS-CoV-2 vs RaTG13 fluctuates over an order of magnitude.
- The amino acid sequences in the receptor binding domain (RBD) of S proteins should best bind to the host’s infected receptors, but RaTG13 and pangolin coronavirus do not bind much to ACE2 of their hosts, horseshoe bat or pangolin.
- The E protein of ZC45, ZXC21, which is coronavirus in bats, is the same as 100% SARS-CoV-2 and could be the backbone of the SARS-CoV-2 gene sequence.
- How the furin-cleavage site inserted at the junction of the S1/S2 region could not be rationally explained from a view point of viral evolution.
When I start reading this paper, I’m drawn in as if I were reading a detective story.
And finally, you will be convinced that the new coronavirus (SARS-CoV-2) could be an artificial product.
By all means, I recommend you to read it.