A group from Chinese Center for Disease Control and Prevention, Beijing etc. has infected gastric epithelial cells (GES-1) with Helicobacter pylori isolated from patients with different diseases, and investigated changes in glycan modification with lectin microarrays.
https://www.mdpi.com/2076-0817/10/2/168/htm
Patient’s disease states from which H. pylori bacteria were isolated were as follows:
Chronic gastritis (YN4-62),
Duodenal ulcer disease (M84, P164),
Gastric cancer (HLJ011, HLJ030),
The trend is characterized by the increase in α1-2Fuc and α2-3Sia modifications. GES-1 which was not infected with H. pylori, was used as a control, to compare changes in glycan expression levels. Red indicates increased ones.
