A group from Okayama University School of Medicine has reported on a study focusing on glycans and lectins as prognosis markers for IgA nephropathy.
https://www.nature.com/articles/s41598-020-77736-1
They have found excellent prognostic markers from urine as a diagnostic sample with using lectin microarrays for 157 IgA nephropathy patients who received a renal biopsy from 2010 to 2017 at Okayama University Hospital.
The prognosis outcome were based on a decrease in glomerular filter rate (eGFR) (> 4 mL/min/1.73 m2/year), or eGFR ≥ 30% decline from baseline. T Score was used for the statistical evaluation, and it was found that ECA lectins (with glycan binding specificity to Galβ1-4GlcNAc) and NPA lectins (with glycan binding specificity to High Mannose) could be good prognostic markers.
ECA:(odds ratio[OR] 2.84, 95% confidence interval[CI] 1.11–7.28)
NPA:(OR 2.32, 95% CI 1.11–4.85)
T Score is calculated by multiplying the standardized percentile rank by 10 and adding 50. T0, T1, T2 indicate Oxford classification about tubular atrophy and interstitial fibrosis.
