A group from Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA, etc. has reported that sulfated glycans and highly negatively charged compounds could show strong antiviral activities against SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875565/
It was know that many sulfated glycans, such as heparin, fucoidans, and rhamnan sulfate show anti-SARS-CoV-2 activities. In this study, a small library of sulfated glycans and highly negatively charged compounds, including pentosan polysulfate (PPS), mucopolysaccharide polysulfate (MPS) were evaluated as antiviral sulfated glycans against SARS-CoV-2.
The neutralizing effect of PPS and MPS on SARS-CoV-2 pseudotyped virus in vitro were confirmed with neutralization assays. The IC50 values of PPS for the WT and Delta variant were 0.45 and 0.07 µg/mL, and the IC50 values of MPS for the WT and Delta variant were 0.42 and 0.28 µg/mL, respectively (see below). These results suggest the potential use of PPS and MPS as therapeutic and/or preventative antiviral drugs.
