{"id":9986,"date":"2022-09-21T07:01:51","date_gmt":"2022-09-20T22:01:51","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9986"},"modified":"2022-09-21T07:01:51","modified_gmt":"2022-09-20T22:01:51","slug":"sars-cov-2%e3%81%ab%e5%af%be%e3%81%99%e3%82%8buda%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%b4%bb%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ab%e5%af%be%e3%81%99%e3%82%8buda%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%b4%bb%e6%80%a7\/","title":{"rendered":"SARS-CoV-2\u306b\u5bfe\u3059\u308bUDA\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027"},"content":{"rendered":"<p>Laboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001UDA\u30ec\u30af\u30c1\u30f3\u306eSARS-CoV-2\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u52b9\u679c\u3044\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9468479\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9468479\/<\/a><\/p>\n<p>UDA \u306f\u3001\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u30ec\u30af\u30c1\u30f3\u306e\u4e2d\u3067\u6700\u5c0f\u306e\u690d\u7269\u30ec\u30af\u30c1\u30f3\u306e\u3072\u3068\u3064\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u4e0a\u306e GlcNAc \u304a\u3088\u3073\u30cf\u30a4\u30de\u30f3\u30ce\u30fc\u30b9\u578b\u7cd6\u9396\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>UDA \u306f\u3001Vero E6 \u7d30\u80de\u306b\u304a\u3051\u308b\u521d\u671f\u306eWuhan-Hu-1\u682a\u306e\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u3092\u9632\u6b62\u3059\u308b\u3060\u3051\u3067\u306a\u304f (IC<sub>50<\/sub> = 225 nM)\u3001\u30a2\u30eb\u30d5\u30a1\u3001\u30d9\u30fc\u30bf\u3001\u30ac\u30f3\u30de\u306a\u3069\u3001\u5e7e\u3064\u304b\u306e SARS-CoV-2 \u5909\u7570\u682a\u306e\u8907\u88fd\u3082\u9632\u6b62\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (IC&lt;sub = 115 \uff5e 171 nM)\u3002\u66f4\u306b\u3001UDA \u306f\u3001U87.ACE2+ \u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u6700\u8fd1\u6d41\u884c\u3057\u3066\u3044\u308b\u30aa\u30df\u30af\u30ed\u30f3\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f (IC<sub>50<\/sub> = 0.9 \u00b5M)\u3002<\/p>\n<p>SPR\u3092\u7528\u3044\u305f\u7d50\u5408\u89e3\u6790\u304b\u3089\u306f\u3001UDA \u306f\u76f4\u63a5\u7684\u306bRBD\u306e\u7af6\u5408\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u304a\u3089\u305a\u3001\u6700\u3082\u5f37\u3044\u76f8\u4e92\u4f5c\u7528\u90e8\u4f4d\u306f RBD \u306b\u4f4d\u7f6e\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-10032\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2-300x269.png\" alt=\"\" width=\"300\" height=\"269\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2-300x269.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2-230x206.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2-350x314.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2-480x431.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/09\/UDA_SARS-CoV-2.png 597w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Laboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology, Immunology and Transplant<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ab%e5%af%be%e3%81%99%e3%82%8buda%e3%81%ae%e6%8a%97%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%b4%bb%e6%80%a7\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-9986","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9986"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9986\/revisions"}],"predecessor-version":[{"id":10035,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9986\/revisions\/10035"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9986"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9986"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}