{"id":990,"date":"2020-10-09T13:34:48","date_gmt":"2020-10-09T04:34:48","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=985"},"modified":"2021-01-27T14:15:09","modified_gmt":"2021-01-27T05:15:09","slug":"mutations-in-s-proteins-of-the-new-coronavirus-sars-cov-2-25-mutations-including-a930v-d614g-a706s-and-a879s","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/mutations-in-s-proteins-of-the-new-coronavirus-sars-cov-2-25-mutations-including-a930v-d614g-a706s-and-a879s\/","title":{"rendered":"Mutations in S-proteins of the new coronavirus (SARS-CoV-2): 25 mutations, including A930V, D614G, A706S, and A879S"},"content":{"rendered":"<p>From the RNA sequence of the new coronavirus (SARS-CoV-2) registered from India in NCBI-Virus-database as of June 6, 2020, a research result has been reported on what mutations occurred compared to the original strain that began to spread in Wuhan, China.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7521409\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7521409\/<\/a><\/p>\n<p>There are 25 mutations, and they are divided into four clusters (1-100, 148-255, 570-680, 820-930).<\/p>\n<p>Mutations in T572I, A879S, A892V, and A930V have caused significant changes in the secondary structure of proteins, T572I causes a structural change to coilded\u2192helix and the other three to helix\u2192beta sheet. Mutations in the A930V, D614G, A706S, and A879S seem to make a relatively large difference in protein structure. Of particular interest is that the mutation of D614G occurs in 88% of RNA sequences, which is a mainstream among new coronaviruses that are spreading in India. For the D614G, it is reported that it promotes the open conformation of RBD, and as a result, the infectivity of the new coronavirus is increased.<\/p>\n<p>R408I, E471Q is said to be a mutation that is seen only in India.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-2073\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4-1024x239.png\" alt=\"\" width=\"696\" height=\"162\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4-1024x239.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4-600x140.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4-300x70.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4-768x180.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/mutations-in-Spike-protein-4.png 1189w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the RNA sequence of the new coronavirus (SARS-CoV-2) registered from India in NCBI-Virus-database as of J<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/mutations-in-s-proteins-of-the-new-coronavirus-sars-cov-2-25-mutations-including-a930v-d614g-a706s-and-a879s\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-990","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=990"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/990\/revisions"}],"predecessor-version":[{"id":2074,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/990\/revisions\/2074"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}