{"id":9706,"date":"2022-08-21T07:59:21","date_gmt":"2022-08-20T22:59:21","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9706"},"modified":"2022-08-21T07:59:21","modified_gmt":"2022-08-20T22:59:21","slug":"%e3%83%92%e3%83%88%e7%95%8c%e9%9d%a2%e6%b4%bb%e6%80%a7%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aad%ef%bc%88human-sp-d%ef%bc%89%e3%81%af%e3%80%81sars-cov-2%e3%81%ae%e7%b5%90%e5%90%88%e3%81%a8dc-sign","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%92%e3%83%88%e7%95%8c%e9%9d%a2%e6%b4%bb%e6%80%a7%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aad%ef%bc%88human-sp-d%ef%bc%89%e3%81%af%e3%80%81sars-cov-2%e3%81%ae%e7%b5%90%e5%90%88%e3%81%a8dc-sign\/","title":{"rendered":"\u30d2\u30c8\u754c\u9762\u6d3b\u6027\u30bf\u30f3\u30d1\u30af\u8ceaD\uff08human SP-D\uff09\u306f\u3001SARS-CoV-2\u306e\u7d50\u5408\u3068DC-SIGN\u767a\u73fe\u7d30\u80de\u3078\u306e\u4fb5\u5165\u3092\u624b\u52a9\u3051\u3059\u308b"},"content":{"rendered":"

College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u754c\u9762\u6d3b\u6027\u30bf\u30f3\u30d1\u30af\u8ceaD\uff08human SP-D\uff09\u306f\u3001SARS-CoV-2\u306e\u7d50\u5408\u3068DC-SIGN\u767a\u73fe\u7d30\u80de\u3078\u306e\u4fb5\u5165\u3092\u624b\u52a9\u3051\u3059\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.960733\/full<\/a><\/p>\n

\u30d2\u30c8SP-D \u306e\u7d44\u63db\u3048\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\uff08rfhSP-D\uff09 \u304c\u3001SARS-CoV-2 \u306e DC-SIGN \u767a\u73fe\u7d30\u80de\u3078\u306e\u7d50\u5408\u3092\u5a92\u4ecb\u3059\u308b\u80fd\u529b\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002 DC-SIGN\u7d30\u80de\u8868\u9762\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u306b\u3001\u5168\u9577\u30d2\u30c8DC-SIGN\u306eDNA\u914d\u5217\u3092\u542b\u3080\u30d7\u30e9\u30b9\u30df\u30c9\u3092HEK 293T\u7d30\u80de\u306b\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3057\u3066\u3001DC-HEK\u7d30\u80de\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u7d30\u80de\u3092rfhSP-D (20\u03bcg\/ml)\u3067\u51e6\u7406\u3057\u305fSARS-CoV-2\u7591\u30a6\u30a4\u30eb\u30b9\u306b\u66b4\u9732\u3057\u307e\u3057\u305f\u3002\u51e6\u7406\u3055\u308c\u305f\u30b5\u30f3\u30d7\u30eb\uff08DC-HEK + SARS-CoV-2\u7591\u30a6\u30a4\u30eb\u30b9 + rfhSP-D\uff09\u3067\u306f\u3001\u672a\u51e6\u7406\u306e\u30b5\u30f3\u30d7\u30eb\uff08DC-HEK + SARS-CoV-2\u7591\u30a6\u30a4\u30eb\u30b9\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7d0450%\u306e\u7d50\u5408\u52b9\u7387\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002
\n\u540c\u69d8\u306e\u5b9f\u9a13\u3092\u3001PMA \u304a\u3088\u3073 IL-4 \u3067\u51e6\u7406\u3059\u308b\u3053\u3068\u3067\u30cd\u30a4\u30c6\u30a3\u30d6 DC-SIGN \u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u305f THP-1 \u7d30\u80de\u3092\u7528\u3044\u3066\u884c\u306a\u3063\u305f\u3068\u3053\u308d\u3001rfhSP-D \u51e6\u7406\u306f\u3001\u672a\u51e6\u7406\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001DC-SIGN \u3092\u767a\u73fe\u3059\u308b THP-1 \u7d30\u80de\u3078\u306eSARS-CoV-2\u7591\u30a6\u30a4\u30eb\u30b9\u306e\u7d50\u5408\u52b9\u7387\u3092\u7d04 25% \u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u5206\u5b50\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066SARS-CoV-2\u304a\u3088\u3073DC-SIGN\u7d50\u5408\u8907\u5408\u4f53\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u30d6\u30e9\u30a4\u30f3\u30c9\u30c9\u30c3\u30ad\u30f3\u30b0\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u8a66\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u4e0a\u4f4d\u306b\u30e9\u30f3\u30af\u4ed8\u3051\u3055\u308c\u305f\u7d50\u5408\u8907\u5408\u4f53\u306e\u5206\u6790\u306b\u3088\u308a\u3001\u30b9\u30d1\u30a4\u30af \u30bf\u30f3\u30d1\u30af\u8cea\u306e NTD\uff08N \u672b\u7aef\u30c9\u30e1\u30a4\u30f3\uff09\u306f\u3001DC-SIGN \u306e CRD \u30c9\u30e1\u30a4\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u66f4\u306b\u3001DC-SIGN \u3068 SP-D \u3092 Spike \u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30c9\u30c3\u30ad\u30f3\u30b0\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u4e09\u8005\u8907\u5408\u4f53\u304c\u751f\u6210\u3055\u308c\u307e\u3057\u305f\u3002\u30c9\u30c3\u30ad\u30f3\u30b0\u3055\u308c\u305f\u4e0a\u4f4d\u3075\u305f\u3064\u306e\u7d50\u5408\u8907\u5408\u4f53\uff08C1 \u3068 C2\uff09\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001C1\u8907\u5408\u4f53\u3068C2\u8907\u5408\u4f53\u306e\u4e21\u65b9\u3067\u3001DC-SIGN\uff08CRD\uff09\u306fSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306eNTD\u30c9\u30e1\u30a4\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u304a\u308a\u3001C1 \u3067\u306f\u3001Spike \u30bf\u30f3\u30d1\u30af\u8cea\u3068 rfhSP-D \u306e\u9593\u306b\u76f4\u63a5\u7684\u306a\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001C2 \u3067\u306f\u3001Spike \u30bf\u30f3\u30d1\u30af\u8cea\u306f SARS-CoV-2\u306eRBD \u3092\u4ecb\u3057\u3066 rfhSP-D \u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

SP-D \u306f RBD \u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001DC-SIGN \u306f SARS-CoV-2 \u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e NTD \u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u3001\u7d50\u8ad6\u3068\u3057\u3066\u3001SP-D \u306f DC-SIGN \u3068 SARS-CoV-2 \u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, UK\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u754c\u9762\u6d3b\u6027\u30bf\u30f3\u30d1\u30af\u8ceaD\uff08huma<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-9706","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9706","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9706"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9706\/revisions"}],"predecessor-version":[{"id":9710,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9706\/revisions\/9710"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9706"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9706"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}