{"id":9703,"date":"2022-08-20T07:01:36","date_gmt":"2022-08-19T22:01:36","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9703"},"modified":"2022-08-20T07:05:04","modified_gmt":"2022-08-19T22:05:04","slug":"ceruloplasmin-with-bisecting-glcnac-could-be-a-good-biomarker-for-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/ceruloplasmin-with-bisecting-glcnac-could-be-a-good-biomarker-for-pancreatic-cancer\/","title":{"rendered":"Ceruloplasmin with bisecting GlcNAc could be a good biomarker for pancreatic cancer"},"content":{"rendered":"

A group from College of Basic Medical Sciences, Dalian Medical University, Dalian, China, etc. has reported that ceruloplasmin with bisecting GlcNAc could be a good biomarker for pancreatic cancer.
\nhttps:\/\/www.mdpi.com\/2073-4409\/11\/15\/2453\/htm<\/a><\/p>\n

Compared with the normal controls (NC) group, the relative abundances of bisecting glycans, mannosylation, and fucosylation were significantly increased in the pancreatic cancer (PC) group. Compared with the acute pancreatitis (AP) group, the relative abundances of bisecting glycans and fucosylation were significantly enhanced in the PC group; however, the relative abundances of fucosylation seemed similar between the NC and AP groups.<\/p>\n

Since glycans are difficult to be developed as biomarkers alone, the serum glycoproteins containing bisecting glycans were pulled down with biotinylated PHA-E lectin and streptavidin agarose beads, and analyzed by nano LC-MS\/MS. As a result, three proteins, Ceruloplasmin (Cp), apolipoprotein E (Apo-E), and transferrin (Tf) were listed as biomarker glycoproteins.<\/p>\n

\"\"<\/a><\/p>\n

Among these candidates, Cp showed the highest performance: the AUC for Cp between NC and AP, NC and PC, and PC and AP, were 0.917, 0.972, and 0.757, respectively.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from College of Basic Medical Sciences, Dalian Medical University, Dalian, China, etc. has reported th<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-9703","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9703"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9703\/revisions"}],"predecessor-version":[{"id":9704,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9703\/revisions\/9704"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}