{"id":965,"date":"2020-10-07T15:27:45","date_gmt":"2020-10-07T06:27:45","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=956"},"modified":"2020-10-07T16:13:00","modified_gmt":"2020-10-07T07:13:00","slug":"fusion-protein-of-lectins-derived-from-ricinus-communis-and-phytolacca-americana-expected-as-a-novel-therapeutic-agent-for-the-new-coronavirus-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/fusion-protein-of-lectins-derived-from-ricinus-communis-and-phytolacca-americana-expected-as-a-novel-therapeutic-agent-for-the-new-coronavirus-covid-19\/","title":{"rendered":"Fusion protein of lectins derived from Ricinus communis and Phytolacca americana expected as a novel therapeutic agent for the new coronavirus (COVID-19)"},"content":{"rendered":"

As a treatment for the new coronavirus (COVID-19), the usefulness of the fusion protein (RTAM-PAP1) between a mutant of the lysine A chain extracted from Ricinus communis (RTAM) and a lectin extracted from the leaves of Phytolacca americana (PAP1) is reported from the viewpoint of affinity evaluation between various proteins of SARS-CoV-2 and RTAM-PAP1 and also from toxicity testing using mice.
\nhttps:\/\/www.mdpi.com\/2072-6651\/12\/9\/602\/htm<\/a><\/p>\n

The binding affinity between a patient-derived antibody B38 of SARS-CoV-2 (as a control), ACE2, RTAM-PAP1 and various proteins of SARS-CoV-2 were evaluated using three-dimensional molecular structure analysis software named CoDockPP, HASSOCK2.2, and ZDOCK. The binding of RTAM-PAP1 was stronger than ACE2, and showed the same binding affinity as B38 comprehensively.
\nIn addition, the toxicity tests using mice showed no side effects even at 1 mg\/kg of dose.<\/p>\n

This paper shows the usefulness of the fusion protein of lectins derived from Ricinus communis and Phytolacca americana as a novel drug for the new coronavirus.<\/p>\n

\"\"<\/a>
\nRicinus communis<\/p>\n

 <\/p>\n

 <\/p>\n

\"\"<\/a>
\nPhytolacca americana<\/p>\n","protected":false},"excerpt":{"rendered":"

As a treatment for the new coronavirus (COVID-19), the usefulness of the fusion protein (RTAM-PAP1) between a <\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-965","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=965"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/965\/revisions"}],"predecessor-version":[{"id":971,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/965\/revisions\/971"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}