{"id":9620,"date":"2022-08-13T08:02:03","date_gmt":"2022-08-12T23:02:03","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9620"},"modified":"2022-08-13T08:07:37","modified_gmt":"2022-08-12T23:07:37","slug":"lectins-specific-to-bisecting-glcnac","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/lectins-specific-to-bisecting-glcnac\/","title":{"rendered":"Lectins specific to bisecting GlcNAc"},"content":{"rendered":"<p>A group from Department of Chemistry, Georgia State University, Atlanta GA USA, etc. has reported about lectins specific to bisecting GlcNAc.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9241959\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9241959\/<\/a><\/p>\n<p>Many plant lectins could tolerate the bisecting GlcNAc, among which the bindings of PHA-E and Calsepa were enhanced. It was observed that even at a low concentration (1 \u03bcg mL\u22121), PHA-E and Calsepa showed bindings to non-bisected N-glycans, which would pose a significant problem in their wide applications of bisected glycan identification and cancer biomarker discovery. Surprisingly, PHA-L exhibited specific recognition of bisected biantennary N-glycans, which could find promising implementation in probing such structures, e.g., in antibodies, where \u03b21-6-branched glycans are absent.<br \/>\nHowever, it should be noted that PHA-L has a strong specificity for tri\/tetra antennary N-glycans.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9615\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-300x182.png\" alt=\"\" width=\"300\" height=\"182\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-300x182.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-600x364.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-768x466.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-230x140.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-350x213.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP-480x292.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/bisectingGlcNAc-and-GBP.png 815w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Chemistry, Georgia State University, Atlanta GA USA, etc. has reported about lectin<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/lectins-specific-to-bisecting-glcnac\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-9620","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9620"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9620\/revisions"}],"predecessor-version":[{"id":9621,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9620\/revisions\/9621"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}