{"id":9571,"date":"2022-08-12T07:45:36","date_gmt":"2022-08-11T22:45:36","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9571"},"modified":"2022-08-12T07:45:36","modified_gmt":"2022-08-11T22:45:36","slug":"%e9%80%b2%e8%a1%8c%e6%80%a7%e5%ad%90%e5%ae%ae%e5%86%85%e8%86%9c%e7%97%87%e3%81%ae%e8%a8%ba%e6%96%ad%e3%81%abigg%e3%81%aeo-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%8c%e3%83%9e%e3%83%bc","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e9%80%b2%e8%a1%8c%e6%80%a7%e5%ad%90%e5%ae%ae%e5%86%85%e8%86%9c%e7%97%87%e3%81%ae%e8%a8%ba%e6%96%ad%e3%81%abigg%e3%81%aeo-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%8c%e3%83%9e%e3%83%bc\/","title":{"rendered":"\u9032\u884c\u6027\u5b50\u5bae\u5185\u819c\u75c7\u306e\u8a3a\u65ad\u306bIgG\u306eO-\u578b\u7cd6\u9396\u4fee\u98fe\u304c\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308a\u5f97\u308b"},"content":{"rendered":"<p>Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Poland\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8840\u6e05 IgG3\u306eO-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u306e\u5909\u5316\u306f\u3001\u9032\u884c\u6027\u5b50\u5bae\u5185\u819c\u75c7\u306b\u304a\u3051\u308b\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308a\u5f97\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8087\/htm\">https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8087\/htm<\/a><\/p>\n<p>\u69cb\u9020\u7684\u306b\u3001\u30d2\u30c8IgG \u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u306f\u901a\u5e38\u3001\u4e8c\u5206\u5c90\u8907\u5408\u578b\u3067\u3059\u3002 \u3082\u3046\u3072\u3068\u3064\u306eN-\u578b\u7cd6\u9396\u4fee\u98fe\u90e8\u4f4d\u306f\u3001VH \u3068 VL (\u305d\u308c\u305e\u308c\u53ef\u5909\u9818\u57df\u306e\u91cd\u9396\u3068\u8efd\u9396) \u306b\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u8840\u6e05IgG \u306e15 \uff5e 25% \u3067\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002 IgG Fab \u9818\u57df\u306b\u7cd6\u9396\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u6297\u4f53\u306e\u5b89\u5b9a\u6027\u304c\u9ad8\u307e\u308a\u3001\u6297\u539f\u7d50\u5408\u304c\u8abf\u7bc0\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 IgG3 \u3067\u306f\u3001Fab \u304a\u3088\u3073 Fc \u9818\u57df\u306b\u5b58\u5728\u3059\u308b N-\u578b\u7cd6\u9396\u3068\u306f\u5225\u306b\u3001\u30d2\u30f3\u30b8\u9818\u57df\u306b O-\u578b\u7cd6\u9396\u306e\u5b58\u5728\u3082\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u8840\u6e05\u4e2d\u306b\u306f\u3001IgG3 \u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306e\u7d04 10%\u3001IgG3 \u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306e\u7d04 13% \u304c O-\u578b\u7cd6\u9396\u4fee\u98fe\u3092\u542b\u3080\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5404 IgG3 \u5206\u5b50\u306f\u3001\u30d2\u30f3\u30b8\u9818\u57df\u5185\u306e\u4e09\u91cd\u53cd\u5fa9\u9818\u57df\u306e\u30b9\u30ec\u30aa\u30cb\u30f3\u6b8b\u57fa\u306b\u7d50\u5408\u3057\u305f\u6700\u5927\u4e09\u3064\u306eO-\u578b\u7cd6\u9396\u3092\u542b\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002IgG O-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u6a5f\u80fd\u306f\u307e\u3060\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30d2\u30f3\u30b8\u9818\u57df\u306e\u69cb\u9020\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u3088\u308b\u5207\u65ad\u304b\u3089\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u3092\u4fdd\u8b77\u3057\u3001IgG3 \u306e\u62e1\u5f35\u69cb\u9020\u3068\u67d4\u8edf\u6027\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u9032\u884c\u6027\u5b50\u5bae\u5185\u819c\u75c7\u306b\u95a2\u3057\u3066\u3001O-\u578b\u7cd6\u9396\u304c\u9032\u884c\u6027\u5b50\u5bae\u5185\u819c\u75c7\u306e\u8840\u6e05IgG \u3067\u767a\u73fe\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u4e8c\u5206\u5c90N-\u578b\u7cd6\u9396\u306e\u5b58\u5728\u306b\u52a0\u3048\u3066\u3001IgG \u306b\u9ad8\u5ea6\u306b\u5206\u5c90\u3057\u305fN-\u578b\u7cd6\u9396\u3082\u5b58\u5728\u3059\u308b\u304b\u3069\u3046\u304b\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8840\u6e05 IgG O-\u578b\u7cd6\u9396\u4fee\u98fe\u304a\u3088\u3073\u591a\u5206\u5c90N-\u578b\u7cd6\u9396\u4fee\u98fe\u306e\u767a\u73fe\u5206\u6790\u306e\u305f\u3081\u306b\u3001O-\u578b\u7cd6\u9396\u8a8d\u8b58\u30ec\u30af\u30c1\u30f3 (MPL\u3001VVL\u3001\u304a\u3088\u3073\u30b8\u30e3\u30ab\u30ea\u30f3) \u304a\u3088\u3073\u591a\u5206\u5c90N-\u578b\u7cd6\u9396\u8a8d\u8b58\u30ec\u30af\u30c1\u30f3 (PHA-L) \u3092\u7528\u3044\u305f\u30ec\u30af\u30c1\u30f3 ELISA \u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30b5\u30f3\u30d7\u30eb\u3068\u3057\u3066\u306f\u3001\u5358\u96e2\u3055\u308c\u305f\u8840\u6e05 IgG\uff08i-IgG\uff09\u3001\u304a\u3088\u3073\u30af\u30eb\u30fc\u30c9\u306a\u8840\u6e05 IgG\uff08s-IgG\uff09\u4e21\u65b9\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u7d50\u679c\u306f\u9a5a\u304f\u3079\u304d\u3082\u306e\u3067\u3057\u305f\u3002 s-IgG\u306e\u5834\u5408\u3001\u81e8\u5e8a\u7684\u4fa1\u5024\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001i-IgG \u306e\u5834\u5408\u3001\u5b50\u5bae\u5185\u819c\u75c7\u304c\u9032\u884c\u3057\u305f\u5973\u6027\u3068\u5065\u5eb7\u306a\u5973\u6027\u3001\u5065\u5eb7\u306a\u5973\u6027\u3068\u975e\u5b50\u5bae\u5185\u819c\u75c7\u30b0\u30eb\u30fc\u30d7\u3092\u6bd4\u8f03\u3057\u305f\u5834\u5408\u306e\u4e21\u65b9\u3067\u3001\u4f7f\u7528\u3057\u305f\u56db\u3064\u306e\u30ec\u30af\u30c1\u30f3\u3059\u3079\u3066\u3067\u6700\u5927\u306e\u81e8\u5e8a\u5024 (AUC = 1) \u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n\u3053\u306e\u7814\u7a76\u306f\u3001IgG \u306b\u304a\u3051\u308b O-\u578b\u7cd6\u9396\u3068\u591a\u5206\u5c90N-\u578b\u7cd6\u9396\u306e\u4e21\u65b9\u306e\u767a\u73fe\u304c\u3001\u9032\u884c\u3057\u305f\u5b50\u5bae\u5185\u819c\u75c7\u306e\u8a3a\u65ad\u306b\u5fdc\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u73fe\u5728\u306e\u7814\u7a76\u6bb5\u968e\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u7d50\u8ad6\u306f\u4e3b\u306b\u8840\u6e05\u304b\u3089\u5358\u96e2\u3055\u308c\u305f IgG \u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u96e2\u3068\u7cbe\u88fd\u306f\u3001\u9762\u5012\u3067\u6642\u9593\u306e\u304b\u304b\u308b\u4f5c\u696d\u3067\u3042\u308a\u3001\u3053\u306e\u7a2e\u306e\u8a3a\u65ad\u6cd5\u3092\u30eb\u30fc\u30c1\u30f3\u306e\u8a3a\u65ad\u306b\u9069\u7528\u3059\u308b\u306b\u306f\u5927\u3044\u306b\u56f0\u96e3\u304c\u4f34\u3044\u307e\u3059\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u306e\u7814\u7a76\u306e\u65b9\u5411\u6027\u306f\u6709\u671b\u3067\u3042\u308b\u3068\u601d\u308f\u308c\u3001\u30b7\u30f3\u30d7\u30eb\u3067\u8fc5\u901f\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u96e2\u624b\u9806\u306e\u958b\u767a\u304c\u5207\u671b\u3055\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Poland\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8840\u6e05 IgG3\u306eO-\u578b<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e9%80%b2%e8%a1%8c%e6%80%a7%e5%ad%90%e5%ae%ae%e5%86%85%e8%86%9c%e7%97%87%e3%81%ae%e8%a8%ba%e6%96%ad%e3%81%abigg%e3%81%aeo-%e5%9e%8b%e7%b3%96%e9%8e%96%e4%bf%ae%e9%a3%be%e3%81%8c%e3%83%9e%e3%83%bc\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-9571","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Division of Laboratory Diagnostics, Faculty of Pharmacy\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" 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