{"id":9513,"date":"2022-08-07T07:43:41","date_gmt":"2022-08-06T22:43:41","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9513"},"modified":"2022-08-07T07:43:41","modified_gmt":"2022-08-06T22:43:41","slug":"sars-cov-2%e3%81%ae%e5%ae%bf%e4%b8%bb%e6%84%9f%e6%9f%93%e9%98%b2%e5%be%a1%e6%a9%9f%e6%a7%8b%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e6%b0%97%e9%81%93%e3%83%a0%e3%83%81%e3%83%b3%e3%81%ae%e5%ad%98%e5%9c%a8","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e5%ae%bf%e4%b8%bb%e6%84%9f%e6%9f%93%e9%98%b2%e5%be%a1%e6%a9%9f%e6%a7%8b%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e6%b0%97%e9%81%93%e3%83%a0%e3%83%81%e3%83%b3%e3%81%ae%e5%ad%98%e5%9c%a8\/","title":{"rendered":"SARS-CoV-2\u306e\u5bbf\u4e3b\u611f\u67d3\u9632\u5fa1\u6a5f\u69cb\u3068\u3057\u3066\u306e\u6c17\u9053\u30e0\u30c1\u30f3\u306e\u5b58\u5728"},"content":{"rendered":"<p>Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001SARS-CoV-2\u611f\u67d3\u306b\u5bfe\u3059\u308b\u4e3b\u8981\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u7d4c\u8def\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41588-022-01131-x\">https:\/\/www.nature.com\/articles\/s41588-022-01131-x<\/a><\/p>\n<p>\u6700\u8fd1\u306e\u6a5f\u80fd\u55aa\u5931 (LOF) \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u3092\u3001SARS-CoV-2\u611f\u67d3\u306b\u304a\u3051\u308b\u5bbf\u4e3b\u56e0\u5b50\u8981\u4ef6\u306e\u63a2\u7d22\u306b\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u975e\u4e0a\u76ae\u7d30\u80de\u682a\u307e\u305f\u306f\u5185\u56e0\u7684\u306bACE2\u304a\u3088\u3073TMPRSS2\u3092\u767a\u73fe\u3057\u306a\u3044\u7d30\u80de\u682a\u306e\u3044\u305a\u308c\u304b\u3067\u3001\u5bbf\u4e3b\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u63a1\u7528\u3055\u308c\u307e\u3059\u3002\u3053\u306eLOF \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u3001\u30d7\u30ed\u30a6\u30a4\u30eb\u30b9\u907a\u4f1d\u5b50\u306e\u540c\u5b9a\u306b\u306f\u5f37\u529b\u3067\u3059\u3002\u4e00\u65b9\u3067\u3001\u6a5f\u80fd\u7372\u5f97 (GOF) \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u7528\u3044\u308c\u3070\u3001\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u6642\u306b\u30a6\u30a4\u30eb\u30b9\u5236\u9650\u3092\u5a92\u4ecb\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u56e0\u5b50\u3092\u540c\u5b9a\u3067\u304d\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u53cc\u65b9\u5411\u306e\u65b9\u6cd5\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u884c\u3059\u308b\u3068\u3001\u30d0\u30a4\u30e2\u30fc\u30c0\u30eb\u306a\u5f79\u5272\u3092\u6301\u3064\u5bbf\u4e3b\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u3001\u30a6\u30a4\u30eb\u30b9\u4f9d\u5b58\u6027\u3068\u5bbf\u4e3b\u6307\u5411\u306e\u5275\u85ac\u958b\u767a\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u306b\u5bfe\u3059\u308b\u3088\u308a\u5305\u62ec\u7684\u306a\u63cf\u50cf\u3092\u63cf\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001\u672c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7d50\u679c\u304b\u3089\u3001G\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53 (GPCR) \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u8ee2\u5199\u8abf\u7bc0 (TAF7L\u3001FOXE1\u3001ZNF275\u3001TEAD3\u3001SPDEF\u3001JDP2)\u3001\u7d30\u80de\u5468\u671f\u8abf\u7bc0 (CCNE1)\u3001\u304a\u3088\u3073\u30e0\u30c1\u30f3\u4fee\u98fe (MUC1\u3001MUC4\u3001MUC13\u3001MUC21\u3001 B3GNT8) \u304c\u3001\u4e3b\u8981\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u7d4c\u8def\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u69d8\u3005\u306aSARS-CoV-2\u81e8\u5e8a\u5206\u96e2\u682a\u306e\u611f\u67d3\u306b\u5bfe\u3059\u308b\u819c\u56fa\u5b9a\u578b\u30e0\u30c1\u30f3\u306e\u5f71\u97ff\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001MUC1 \u304a\u3088\u3073 MUC4 GOF Calu-3 \u7cfb\u7d71\u306b\u30a2\u30eb\u30d5\u30a1\u3001\u30d9\u30fc\u30bf\u3001\u30ac\u30f3\u30de\u3001\u30a4\u30d7\u30b7\u30ed\u30f3\u3001\u30c7\u30eb\u30bf\u5909\u7570\u682a\u3001\u304a\u3088\u3073 WA\/1 \u91ce\u751f\u682a\u3092\u611f\u67d3\u3055\u305b\u307e\u3057\u305f\u3002 MUC1\u307e\u305f\u306fMUC4\u306e\u3044\u305a\u308c\u304b\u306e\u904e\u5270\u767a\u73fe\u306f\u3001NTG\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u3053\u308c\u3089SARS-CoV-2\u5909\u7570\u682a\u306e\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u3092\u5236\u9650\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u66f4\u306b\u3001\u30e0\u30c1\u30f3\u9078\u629e\u7684\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc (StcE) \u51e6\u7406\u3068\u305d\u308c\u306b\u7d9a\u304f\u3053\u308c\u3089\u306e\u540c\u3058\u5909\u7570\u682a\u306e\u611f\u67d3\u5b9f\u611f\u306b\u304a\u3044\u3066\u3001Calu-3\u7d30\u80de\u306f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u5bfe\u3057\u3066\u6709\u610f\u306b\u5f31\u304f\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u819c\u56fa\u5b9a\u30e0\u30c1\u30f3\u304c\u3001SARS-CoV-2\u5909\u7570\u682a\u306e\u611f\u67d3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-300x108.png\" alt=\"\" width=\"300\" height=\"108\" class=\"alignnone size-medium wp-image-9515\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-300x108.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-600x215.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-768x275.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-230x82.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-350x126.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-480x172.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2-800x287.png 800w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/08\/mucin-and-SARS-CoV-2.png 909w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2%e3%81%ae%e5%ae%bf%e4%b8%bb%e6%84%9f%e6%9f%93%e9%98%b2%e5%be%a1%e6%a9%9f%e6%a7%8b%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e6%b0%97%e9%81%93%e3%83%a0%e3%83%81%e3%83%b3%e3%81%ae%e5%ad%98%e5%9c%a8\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-9513","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9513"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9513\/revisions"}],"predecessor-version":[{"id":9518,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9513\/revisions\/9518"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}