{"id":9422,"date":"2022-08-01T06:25:11","date_gmt":"2022-07-31T21:25:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9422"},"modified":"2022-08-01T06:21:33","modified_gmt":"2022-07-31T21:21:33","slug":"a-lectin-fc-fusion-protein-i-e-lectibody-recognizing-cancer-specific-high-mannose-glycans-would-be-a-useful-drug-in-cancer-therapy","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-lectin-fc-fusion-protein-i-e-lectibody-recognizing-cancer-specific-high-mannose-glycans-would-be-a-useful-drug-in-cancer-therapy\/","title":{"rendered":"A lectin-Fc fusion protein (i.e., lectibody) recognizing cancer specific high mannose glycans would be a useful drug in cancer therapy"},"content":{"rendered":"<p>A group from Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY, USA, etc. has reported that a lectin-Fc fusion protein (i.e., lectibody) recognizing cancer specific high mannose glycans would be a useful drug in cancer therapy.<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pbi.13902\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pbi.13902<\/a><\/p>\n<p>Avaren-Fc (AvFc) is a lectin-Fc fusion protein (i.e., lectibody) produced in Nicotiana benthamiana, which selectively recognizes cancer-associated high-mannose glycans. A glycovariant of AvFc (AvFc<sup>\u0394XF<\/sup>) was developed by eliminating plant glycans, including the core\u03b11,3-fucoseand \u03b21,2-xylose residues. The successful removal of these glycans was confirmed by glycan analysis using HPLC.<\/p>\n<p>This study has demonstrated that AvFc<sup>\u0394XF<\/sup> induces more a potent ADCC response in vitro and delays the growth of murine B16F10 melanoma in both a flank tumor model as well as a model of metastasisin vivo, suggesting that high mannose glycans may be a useful druggable biomarker in cancer therapy.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9418\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-231x300.png\" alt=\"\" width=\"231\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-231x300.png 231w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-230x299.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer.png 306w\" sizes=\"auto, (max-width: 231px) 100vw, 231px\" \/><\/a> where, AvFc<sup>\u0394lec<\/sup> means a variant lacking sugar-binding activity<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY, USA, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-lectin-fc-fusion-protein-i-e-lectibody-recognizing-cancer-specific-high-mannose-glycans-would-be-a-useful-drug-in-cancer-therapy\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-9422","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9422"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9422\/revisions"}],"predecessor-version":[{"id":9423,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9422\/revisions\/9423"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}