{"id":9417,"date":"2022-08-01T06:25:11","date_gmt":"2022-07-31T21:25:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9417"},"modified":"2022-08-01T06:21:08","modified_gmt":"2022-07-31T21:21:08","slug":"%e3%81%8c%e3%82%93%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aahigh-mannose%e5%9e%8b%e7%b3%96%e9%8e%96%e3%82%92%e8%aa%8d%e8%ad%98%e3%81%99%e3%82%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-fc%e8%9e%8d%e5%90%88","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%81%8c%e3%82%93%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aahigh-mannose%e5%9e%8b%e7%b3%96%e9%8e%96%e3%82%92%e8%aa%8d%e8%ad%98%e3%81%99%e3%82%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-fc%e8%9e%8d%e5%90%88\/","title":{"rendered":"\u304c\u3093\u7279\u7570\u7684\u306aHigh mannose\u578b\u7cd6\u9396\u3092\u8a8d\u8b58\u3059\u308b\u30ec\u30af\u30c1\u30f3-Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u3059\u306a\u308f\u3061\u3001\u30ec\u30af\u30c6\u30a3\u30dc\u30c7\u30a3\uff09\u306f\u3001\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u6709\u7528\u306a\u6cbb\u7642\u85ac\u3068\u306a\u308b"},"content":{"rendered":"<p>Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u304c\u3093\u7279\u7570\u7684\u306aHigh mannose\u578b\u7cd6\u9396\u3092\u8a8d\u8b58\u3059\u308b\u30ec\u30af\u30c1\u30f3-Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u3059\u306a\u308f\u3061\u3001\u30ec\u30af\u30c6\u30a3\u30dc\u30c7\u30a3\uff09\u306f\u3001\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u6709\u7528\u306a\u85ac\u5264\u3068\u306a\u308a\u5f97\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pbi.13902\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pbi.13902<\/a><\/p>\n<p>Avaren-Fc (AvFc) \u306f\u3001\u30cb\u30b3\u30c1\u30a2\u30ca \u30d9\u30f3\u30b5\u30df\u30a2\u30ca\uff08\u690d\u7269\u306e\u30bf\u30d0\u30b3\uff09\u3067\u7523\u751f\u3055\u308c\u308b\u30ec\u30af\u30c1\u30f3-Fc \u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea (\u3059\u306a\u308f\u3061\u3001\u30ec\u30af\u30c6\u30a3\u30dc\u30c7\u30a3) \u3067\u3042\u308a\u3001\u304c\u3093\u95a2\u9023\u306eHigh mannose\u578b\u7cd6\u9396\u3092\u9078\u629e\u7684\u306b\u8a8d\u8b58\u3057\u307e\u3059\u3002AvFc\u306e\u7cd6\u9396\u6539\u5909\u4f53 (AvFc<sup>\u0394XF<\/sup>) \u306f\u3001\u30b3\u30a2\u03b11,3-\u30d5\u30b3\u30fc\u30b9\u304a\u3088\u3073\u03b21,2-\u30ad\u30b7\u30ed\u30fc\u30b9\u6b8b\u57fa\u3092\u542b\u3080\u690d\u7269\u306b\u7279\u6709\u306a\u7cd6\u9396\u3092\u9664\u53bb\u3057\u305f\u3082\u306e\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7cd6\u9396\u306e\u9664\u53bb\u304c\u6210\u529f\u3057\u305f\u3053\u3068\u306f\u3001HPLC\u3092\u4f7f\u7528\u3057\u305f\u7cd6\u9396\u5206\u6790\u306b\u3088\u3063\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001AvFc<sup>\u0394XF<\/sup> \u304c in vitro \u3067\u3088\u308a\u5f37\u529b\u306aADCC\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u3001in vivo\u3067\u306e\u764c\u8ee2\u79fb\u30e2\u30c7\u30eb\u3068\u540c\u69d8\u306b\u5074\u8179\u90e8\u816b\u760d\u30e2\u30c7\u30eb\u306e\u4e21\u65b9\u3067\u30de\u30a6\u30b9B16F10\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u6210\u9577\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3001High mannose\u578b\u7cd6\u9396\u304c\u764c\u6cbb\u7642\u306b\u304a\u3051\u308b\u6709\u7528\u306a\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9418\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-231x300.png\" alt=\"\" width=\"231\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-231x300.png 231w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer-230x299.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/AvFc_Cancer.png 306w\" sizes=\"auto, (max-width: 231px) 100vw, 231px\" \/><\/a> \u3053\u3053\u3067\u3001AvFc<sup>\u0394lec<\/sup> \u306f\u3001\u7cd6\u9396\u7d50\u5408\u7279\u7570\u6027\u3092\u6b20\u304f\u5909\u7570\u4f53\u3092\u610f\u5473\u3057\u307e\u3059<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Pharmacology and Toxicology, University of Louisville School of Medicine, KY, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u304c\u3093\u7279\u7570\u7684\u306aH<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%81%8c%e3%82%93%e7%89%b9%e7%95%b0%e7%9a%84%e3%81%aahigh-mannose%e5%9e%8b%e7%b3%96%e9%8e%96%e3%82%92%e8%aa%8d%e8%ad%98%e3%81%99%e3%82%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3-fc%e8%9e%8d%e5%90%88\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-9417","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9417"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9417\/revisions"}],"predecessor-version":[{"id":9421,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9417\/revisions\/9421"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}