{"id":9326,"date":"2022-07-26T14:11:31","date_gmt":"2022-07-26T05:11:31","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9326"},"modified":"2022-07-27T06:12:25","modified_gmt":"2022-07-26T21:12:25","slug":"a-lectin-domain-exists-in-mouse-n-acetylglucosaminyltransferase-iva-mgat4a-gnt-iva-c-terminal-region","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-lectin-domain-exists-in-mouse-n-acetylglucosaminyltransferase-iva-mgat4a-gnt-iva-c-terminal-region\/","title":{"rendered":"A  lectin domain exists in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A: GnT-IVa) C-terminal region"},"content":{"rendered":"<p>A group from Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan, etc. has discovered a lectin domain in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A: GnT-IVa) C-terminal region.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9296478\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9296478\/<\/a><\/p>\n<p>The biosynthesis of the GlcNAc branches existing in N-glycans is catalyzed by the specific N-acetylglucosaminyltransferases (GnTs), GnT-I to -V.<\/p>\n<p>Authors have found that the lectin domain discovered in GnT-IVa forms a \u03b2-sandwich fold composed of nine \u03b2-strands with three short \u03b1-helices, and this domain shows structural and functional similarities with bacterial CBM32 acting\u00a0as a lectin with a preference for GlcNAc.<\/p>\n<p>It was also found that the lectin domain of GnT-IVa is required for the efficient N-glycan biosynthesis toward glycoprotein substrates in cells.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9314\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-300x178.png\" alt=\"\" width=\"300\" height=\"178\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-300x178.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-600x357.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-768x457.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-920x547.png 920w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-230x137.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-350x208.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-480x285.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa-800x476.png 800w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/lectin-domain-in-GnT-IVa.png 972w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-lectin-domain-exists-in-mouse-n-acetylglucosaminyltransferase-iva-mgat4a-gnt-iva-c-terminal-region\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-9326","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9326"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9326\/revisions"}],"predecessor-version":[{"id":9327,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9326\/revisions\/9327"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}