{"id":9199,"date":"2022-07-23T08:43:13","date_gmt":"2022-07-22T23:43:13","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9199"},"modified":"2022-07-25T04:54:27","modified_gmt":"2022-07-24T19:54:27","slug":"glycan-features-defining-cells-differentially-susceptible-to-hiv-single-cell-level-study","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/glycan-features-defining-cells-differentially-susceptible-to-hiv-single-cell-level-study\/","title":{"rendered":"Glycan features defining cells differentially susceptible to HIV: Single-cell level study"},"content":{"rendered":"<p>A group from Department of Urology, University of California, San Francisco, USA, etc. has reported that HIV upregulates the levels of cell-surface fucose and sialic acid in a cell-intrinsic manner, and that memory CD4+ T cells co-expressing high levels of fucose and sialic acid are highly susceptible to HIV infection.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9255966\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9255966\/<\/a><\/p>\n<p>Glycans were remodeled on the surface of HIV-infected cells. Both total sialic acid (recognized by WGA, which also binds to N-acetylglucosamine) and \u03b12\u20133 linked sialic acid (recognized by MAL-1) were upregulated by HIV during infection as shown below.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV_fucoseSialicAcid.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9195\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV_fucoseSialicAcid-300x271.png\" alt=\"\" width=\"300\" height=\"271\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV_fucoseSialicAcid-300x271.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV_fucoseSialicAcid-600x542.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV_fucoseSialicAcid.png 688w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> where, uninfected (UI), predicted precursor (PRE), and infected (INF) CD4+ cells.<\/p>\n<p>In addition, it was confirmed that HIV preferentially infects memory CD4+ T cells from tonsils and PBMCs co-expressing high levels of fucose and sialic acid.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV-infectivity-with-AOLWGA_lowhigh.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9196\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV-infectivity-with-AOLWGA_lowhigh-300x265.png\" alt=\"\" width=\"300\" height=\"265\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV-infectivity-with-AOLWGA_lowhigh-300x265.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/HIV-infectivity-with-AOLWGA_lowhigh.png 442w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> here, infectivity was assessed by HSA positivity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Urology, University of California, San Francisco, USA, etc. has reported that HIV u<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/glycan-features-defining-cells-differentially-susceptible-to-hiv-single-cell-level-study\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-9199","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9199"}],"version-history":[{"count":6,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9199\/revisions"}],"predecessor-version":[{"id":9247,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9199\/revisions\/9247"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}