{"id":919,"date":"2020-10-06T18:37:33","date_gmt":"2020-10-06T09:37:33","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=919"},"modified":"2021-07-22T00:03:59","modified_gmt":"2021-07-21T15:03:59","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e6%84%9f%e6%9f%93%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e6%84%9f%e6%9f%93%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u611f\u67d3\u963b\u5bb3\u5264\u306b\u3064\u3044\u3066\uff1a\u30d5\u30fc\u30ea\u30f3\u3001II\u578b\u819c\u8cab\u901a\u578b\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3089\u306e\u963b\u5bb3\u5264\u306f\u6709\u52b9\u304b\uff1f"},"content":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306eS\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u611f\u67d3\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308bS1\u90e8\u4f4d\u3068\u7d30\u80de\u819c\u878d\u5408\u306b\u95a2\u4e0e\u3059\u308bS2\u90e8\u4f4d\u306b\u5927\u304d\u304f\u5206\u304b\u308c\u307e\u3059\u3002\u3053\u306eS1\u90e8\u4f4d\u3068S2\u90e8\u4f4d\u306e\u5883\u754c\u306b\u306f\u30d5\u30fc\u30ea\u30f3\u5207\u65ad\u90e8\u4f4d\uff08furin cleavage site\uff09\u304c\u5b58\u5728\u3057\u3001S2\u90e8\u4f4d\u5185\u306b\u306fII\u578b\u819c\u8cab\u901a\u578b\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08transmembrane protease serine 2\uff1aTMPRSS2\uff09\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u90e8\u4f4d\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u90e8\u4f4d\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u5264\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u3092\u62bc\u3055\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u7814\u7a76\u6210\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211-1247(20)31243-2\">https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211-1247(20)31243-2<\/a><\/p>\n<p>decanoyl-RVKR-chloromethylketone\uff08CMK\uff09\uff1afurin\u963b\u5bb3\u5264\u3001camostat\uff1aTMPRSS2\u963b\u5bb3\u5264\u3001\u305d\u308c\u306b\u52a0\u3048\u3066RNA\u306e\u8907\u88fd\u3092\u963b\u5bb3\u3059\u308bnaphthofluorescein\u3089\u304c\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002\u5b9f\u9a13\u306b\u306fVeroE6\u7d30\u80de\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/furin-etc.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-922\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/furin-etc-150x150.png\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/furin-etc-150x150.png 150w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/10\/furin-etc-100x100.png 100w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u85ac\u52b9\u3068\u6bd2\u6027\u3092\u691c\u8a0e\u3057\u305f\u7d50\u679c\u300150%\u963b\u5bb3\u6fc3\u5ea6 (IC50) \u306f\u30010.057 \u03bcM:&nbsp;CMK\u30019.025 \u03bcM: naphthofluorescein\u3001\u305d\u3057\u3066 0.025 \u03bcM: camostat\u3068\u306a\u308a\u307e\u3057\u305f\u3002 50% \u7d30\u80de\u6bd2\u6027\u6fc3\u5ea6 (CC50) \u306f\u3001318.2 \u03bcM: CMK\u300157.44 \u03bcM: naphthofluorescein\u3001\u305d\u3057\u30662,000 \u03bcM: camostat\u3067\u3057\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u306e\u9078\u629e\u6307\u6570\u306f\u30015,567: CMK\u30016.36:&nbsp;naphthofluorescein\u3001\u305d\u3057\u3066 81,004: camostat\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>CMK\u3068camostat\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u521d\u671f\u611f\u67d3\u3092\u963b\u6b62\u3057\u3001naphthofluorescein\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u8907\u88fd\u3092\u963b\u6b62\u3059\u308b\u3001\u3068\u3044\u3046\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u306b\u6ce8\u610f\u3057\u307e\u3057\u3087\u3046\u3002\u4eca\u5f8c\u306e\u8a3a\u65ad\u85ac\u958b\u767a\u306e\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3057\u3066\u66f4\u306a\u308b\u691c\u8a0e\u3092\u671f\u5f85\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306eS\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u611f\u67d3\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308bS1\u90e8\u4f4d\u3068\u7d30\u80de\u819c\u878d\u5408\u306b\u95a2\u4e0e\u3059\u308bS2\u90e8\u4f4d\u306b\u5927\u304d\u304f\u5206\u304b\u308c\u307e\u3059\u3002\u3053\u306eS1\u90e8\u4f4d\u3068S2\u90e8\u4f4d\u306e\u5883\u754c\u306b\u306f\u30d5\u30fc\u30ea\u30f3\u5207\u65ad\u90e8\u4f4d\uff08furin cleavage s<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e6%84%9f%e6%9f%93%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-919","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=919"}],"version-history":[{"count":14,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/919\/revisions"}],"predecessor-version":[{"id":5191,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/919\/revisions\/5191"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}