{"id":9099,"date":"2022-07-12T06:20:26","date_gmt":"2022-07-11T21:20:26","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9099"},"modified":"2022-07-12T06:28:00","modified_gmt":"2022-07-11T21:28:00","slug":"silencing-galactin-1-could-be-effective-in-suppressing-glioblastoma","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/silencing-galactin-1-could-be-effective-in-suppressing-glioblastoma\/","title":{"rendered":"Silencing Galactin-1 could be effective in suppressing Glioblastoma"},"content":{"rendered":"<p>A group from Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL USA, etc. has reported that Galectin-1 activates carbonic anhydrase IX and modulates glioma metabolism.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9247167\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9247167\/<\/a><\/p>\n<p>Galectin 1 (Gal-1) and Galectin 3 (Gal-3) have been studied in relation to Glioblastoma (GBM). Gal-1 binds intact \u03b2-galactose molecules on the cell surface and extracellular matrix. Accumulating evidence shows that Gal-1 plays an important role in cancer (colon, breast, lung, head and neck, prostate cancer, and GBM) since its expression correlates with tumor aggressiveness such as proliferation, invasion and progression.<\/p>\n<p>This report highlights that Gal-1 plays an important role in GBM Stem Cell (GSC) metabolism through mechanisms mediated by carbonic anhydrase IX (CA-IX), the surrogate marker of hypoxia. Gal-1 is under the transcriptional control of HIF-1\u03b1, and in turn, Gal-1 exerts its metabolic influence via physical association with CA-IX. Silencing Gal-1 reverses the Warburg effect by reducing the expression of CA-IX. Thus, targeting the Gal-1\/CA-IX signaling pathway provides a new strategy for reversing the Warburg effect in GBM and inhibiting the progression of GSC-induced cancer growth.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9096\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC-300x230.png\" alt=\"\" width=\"300\" height=\"230\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC-300x230.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC.png 314w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\nwhere, GAPHD: Glyceraldehyde 3-phosphate dehydrogenase; NPC: neural progenitor cells<\/p>\n<p>Silencing Gal-1 made to live longer in mice models.<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9097\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing-300x225.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing.png 418w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peor<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/silencing-galactin-1-could-be-effective-in-suppressing-glioblastoma\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-9099","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9099"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9099\/revisions"}],"predecessor-version":[{"id":9100,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9099\/revisions\/9100"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9099"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}