{"id":9093,"date":"2022-07-12T06:20:26","date_gmt":"2022-07-11T21:20:26","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=9093"},"modified":"2022-07-12T09:39:35","modified_gmt":"2022-07-12T00:39:35","slug":"%e7%a5%9e%e7%b5%8c%e8%86%a0%e8%85%ab%e5%b9%b9%e7%b4%b0%e8%83%9e%e3%81%ae%e6%88%90%e9%95%b7%e3%81%a8%e4%bb%a3%e8%ac%9d%e3%81%ae%e5%86%8d%e3%83%97%e3%83%ad%e3%82%b0%e3%83%a9%e3%83%9f%e3%83%b3%e3%82%b0","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e7%a5%9e%e7%b5%8c%e8%86%a0%e8%85%ab%e5%b9%b9%e7%b4%b0%e8%83%9e%e3%81%ae%e6%88%90%e9%95%b7%e3%81%a8%e4%bb%a3%e8%ac%9d%e3%81%ae%e5%86%8d%e3%83%97%e3%83%ad%e3%82%b0%e3%83%a9%e3%83%9f%e3%83%b3%e3%82%b0\/","title":{"rendered":"\u795e\u7d4c\u81a0\u816b\u5e79\u7d30\u80de\u306e\u6210\u9577\u3068\u4ee3\u8b1d\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u304a\u3051\u308bGalectin-1\u306e\u5f79\u5272"},"content":{"rendered":"<p>Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, IL USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001Gal-1\u304c\u795e\u7d4c\u81a0\u816b\u5e79\u7d30\u80de\u306e\u6210\u9577\u3068\u4ee3\u8b1d\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9247167\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9247167\/<\/a><\/p>\n<p>\u30ac\u30ec\u30af\u30c1\u30f31\uff08Gal-1\uff09\u3068\u30ac\u30ec\u30af\u30c1\u30f33\uff08Gal-3\uff09\u306f\u3001\u795e\u7d4c\u81a0\u816b\u306b\u95a2\u9023\u3057\u3066\u826f\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002 Gal-1\u306f\u3001\u7d30\u80de\u8868\u9762\u304a\u3088\u3073\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u4e0a\u306e\u03b2-\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\u5206\u5b50\u306b\u7d50\u5408\u3057\u307e\u3059\u3002\u904e\u53bb\u306e\u591a\u304f\u306e\u7814\u7a76\u306f\u3001Gal-1\u306e\u767a\u73fe\u304c\u816b\u760d\uff08\u7d50\u8178\u764c\u3001\u4e73\u764c\u3001\u80ba\u764c\u3001\u982d\u9838\u90e8\u764c\u3001\u524d\u7acb\u817a\u764c\u3001\u304a\u3088\u3073\u795e\u7d4c\u81a0\u816b\uff09\u306e\u5897\u6b96\u3084\u6d78\u6f64\u3068\u8a00\u3063\u305f\u653b\u6483\u6027\u306e\u9ad8\u3055\u3068\u60aa\u6027\u5ea6\u306e\u9032\u884c\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001Gal-1\u304c\u764c\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u306f\u3001Gal-1\u304c\u4f4e\u9178\u7d20\u75c7\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u70ad\u9178\u8131\u6c34\u9175\u7d20IX\uff08CA-IX\uff09\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u3066\u3001\u795e\u7d4c\u81a0\u816b\u5e79\u7d30\u80de\uff08GSC\uff09\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002 Gal-1\u306fHIF-1\u03b1\u306e\u8ee2\u5199\u5236\u5fa1\u4e0b\u306b\u3042\u308a\u3001Gal-1\u306fCA-IX\u3068\u306e\u7269\u7406\u7684\u7d50\u5408\u3092\u4ecb\u3057\u3066\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002Gal-1\u3092\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3068\u3001CA-IX\u306e\u767a\u73fe\u304c\u6e1b\u5c11\u3059\u308b\u305f\u3081\u3001\u30ef\u30fc\u30eb\u30d6\u30eb\u30af\u52b9\u679c\u304c\u9006\u8ee2\u3057\u307e\u3059\u3002\u5f93\u3063\u3066\u3001Gal-1\/CA-IX\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306f\u3001\u795e\u7d4c\u81a0\u816b\u306b\u304a\u3051\u308b\u30ef\u30fc\u30eb\u30d6\u30eb\u30af\u52b9\u679c\u3092\u9006\u8ee2\u3055\u305b\u3001\u795e\u7d4c\u81a0\u816b\u5e79\u7d30\u80de\u8a98\u767a\u6027\u306e\u764c\u5897\u6b96\u306e\u9032\u884c\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u6226\u7565\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9096\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC-300x230.png\" alt=\"\" width=\"300\" height=\"230\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC-300x230.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1_GSC.png 314w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\nwhere, GAPHD: Glyceraldehyde 3-phosphate dehydrogenase; NPC: neural progenitor cells<\/p>\n<p>\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001Gal-1\u306e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u304c\u751f\u5b58\u7387\u3092\u5927\u304d\u304f\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-9097\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing-300x225.png\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing-300x225.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/07\/Gal-1-Silencing.png 418w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, IL USA\u3089\u306e\u30b0<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e7%a5%9e%e7%b5%8c%e8%86%a0%e8%85%ab%e5%b9%b9%e7%b4%b0%e8%83%9e%e3%81%ae%e6%88%90%e9%95%b7%e3%81%a8%e4%bb%a3%e8%ac%9d%e3%81%ae%e5%86%8d%e3%83%97%e3%83%ad%e3%82%b0%e3%83%a9%e3%83%9f%e3%83%b3%e3%82%b0\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-9093","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=9093"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9093\/revisions"}],"predecessor-version":[{"id":9104,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/9093\/revisions\/9104"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=9093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=9093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=9093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}