{"id":8946,"date":"2022-06-12T09:47:52","date_gmt":"2022-06-12T00:47:52","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8946"},"modified":"2022-06-12T09:49:21","modified_gmt":"2022-06-12T00:49:21","slug":"galectin-1-plays-important-role-in-the-process-of-h-1-parvovirus-infection","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/galectin-1-plays-important-role-in-the-process-of-h-1-parvovirus-infection\/","title":{"rendered":"Galectin-1 plays important role in the process of H-1 Parvovirus infection"},"content":{"rendered":"

A group from Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Centre, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany, etc. has reported about the importance of Galectin-1 in the process of H-1 Parvovirus infection.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9146882\/<\/a><\/p>\n

Oncolytic viruses selectively infect and destroy cancer cells while sparing normal tissues. They can also stimulate strong anti-tumour immune responses and destroy tumour vasculature. No fewer than 40 oncolytic viruses are currently under evaluation in clinical trials as treatments against a variety of cancers. Among them is H-1 rat protoparvovirus (H-1PV), a member of the Parvoviridae family in the genus Protoparvovirus.<\/p>\n

It was found that H-1PV enters cancer cells via clathrin-mediated endocytosis, a process that involves dynamin and requires a low pH in the endocytic compartments. It was also found that laminins, in particular those containing the laminin \u03b31 chain, act as attachment factors at the cell surface for a successful H-1PV infection. In particular, sialic acid moieties in the laminins provide a docking place for the virus to anchor to at the cell surface, and Gal-1 promotes the efficient internalisation of virus particles into a clathrin-coated pit. After engagement of these factors, H-1PV penetrates the cells preferentially via clathrin-mediated endocytosis.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Centre, Im Neuenheimer <\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8946","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t