{"id":8946,"date":"2022-06-12T09:47:52","date_gmt":"2022-06-12T00:47:52","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8946"},"modified":"2022-06-12T09:49:21","modified_gmt":"2022-06-12T00:49:21","slug":"galectin-1-plays-important-role-in-the-process-of-h-1-parvovirus-infection","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/galectin-1-plays-important-role-in-the-process-of-h-1-parvovirus-infection\/","title":{"rendered":"Galectin-1 plays important role in the process of H-1 Parvovirus infection"},"content":{"rendered":"<p>A group from Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Centre, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany, etc. has reported about the importance of Galectin-1 in the process of H-1 Parvovirus infection.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9146882\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9146882\/<\/a><\/p>\n<p>Oncolytic viruses selectively infect and destroy cancer cells while sparing normal tissues. They can also stimulate strong anti-tumour immune responses and destroy tumour vasculature. No fewer than 40 oncolytic viruses are currently under evaluation in clinical trials as treatments against a variety of cancers. Among them is H-1 rat protoparvovirus (H-1PV), a member of the Parvoviridae family in the genus Protoparvovirus.<\/p>\n<p>It was found that H-1PV enters cancer cells via clathrin-mediated endocytosis, a process that involves dynamin and requires a low pH in the endocytic compartments. It was also found that laminins, in particular those containing the laminin \u03b31 chain, act as attachment factors at the cell surface for a successful H-1PV infection. In particular, sialic acid moieties in the laminins provide a docking place for the virus to anchor to at the cell surface, and Gal-1 promotes the efficient internalisation of virus particles into a clathrin-coated pit. After engagement of these factors, H-1PV penetrates the cells preferentially via clathrin-mediated endocytosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Centre, Im Neuenheimer <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/galectin-1-plays-important-role-in-the-process-of-h-1-parvovirus-infection\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8946","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8946"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8946\/revisions"}],"predecessor-version":[{"id":8947,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8946\/revisions\/8947"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}