{"id":8928,"date":"2022-06-11T06:47:06","date_gmt":"2022-06-10T21:47:06","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8928"},"modified":"2022-06-13T06:49:34","modified_gmt":"2022-06-12T21:49:34","slug":"%e3%83%92%e3%83%88%e3%81%a8%e5%85%b1%e7%94%9f%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b%e8%85%b8%e5%86%85%e7%b4%b0%e8%8f%8c%e3%81%8c%e6%8c%81%e3%81%a4%e6%a9%9f%e8%83%bd%e3%81%8c%e3%81%be%e3%81%a0%e8%89%af","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%83%92%e3%83%88%e3%81%a8%e5%85%b1%e7%94%9f%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b%e8%85%b8%e5%86%85%e7%b4%b0%e8%8f%8c%e3%81%8c%e6%8c%81%e3%81%a4%e6%a9%9f%e8%83%bd%e3%81%8c%e3%81%be%e3%81%a0%e8%89%af\/","title":{"rendered":"\u30d2\u30c8\u3068\u5171\u751f\u3057\u3066\u3044\u308b\u8178\u5185\u7d30\u83cc\u304c\u6301\u3064\u6a5f\u80fd\u304c\u307e\u3060\u826f\u304f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u30ec\u30af\u30c1\u30f3"},"content":{"rendered":"<p>Department of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30d2\u30c8\u306e\u8178\u5185\u5171\u751f\u5fae\u751f\u7269\u53e2\u306b\u304a\u3051\u308b\u7d30\u83cc\u30ec\u30af\u30c1\u30f3\u306e\u89e3\u660e\u6a5f\u80fd\u3068\u591a\u69d8\u6027\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-29949-3\">https:\/\/www.nature.com\/articles\/s41467-022-29949-3<\/a><\/p>\n<p>\u8907\u6570\u306e\u60a3\u8005\u306e\u4fbf\u30b5\u30f3\u30d7\u30eb\u306e\u5171\u751f\u8178\u5185\u7d30\u83cc\u304b\u3089\u898b\u3064\u304b\u3063\u305f\u3072\u3068\u3064\u306e\u5171\u751f\u7d30\u83cc\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u907a\u4f1d\u5b50\uff08Cbeg\uff09\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001\u30ec\u30af\u30c1\u30f3\u3092\u30b3\u30fc\u30c9\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u308b\u307e\u3060\u826f\u304f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u907a\u4f1d\u5b50\uff08Cbeg4\u3084Cbeg5\u306a\u3069\uff09\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>Cbeg4\u3068Cbeg5\u306e\u4e88\u6e2c\u30c9\u30e1\u30a4\u30f3\u5206\u6790\u306b\u3088\u308a\u3001\u4e21\u65b9\u306e\u907a\u4f1d\u5b50\u304c\u5206\u6ccc\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\u3001\u30d5\u30a3\u30d6\u30ed\u30cd\u30af\u30c1\u30f33\u578b\u30c9\u30e1\u30a4\u30f3\uff08Fn; IPR003961\uff09\u304a\u3088\u3073\u7cd6\u9396\u7d50\u5408\u30e2\u30b8\u30e5\u30fc\u30eb\u30c9\u30e1\u30a4\u30f3\uff08CBM\u3001CBM6-CBM35-CBM36_like_2\u3001IPR033803\uff09\u3092\u542b\u3080\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002 Uniprot\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u898b\u3064\u304b\u3063\u305fCBM6-CBM35-CBM36_like_2 \u7cd6\u9396\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3092\u542b\u3080\u3068\u4e88\u6e2c\u3055\u308c\u308b865\u500b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u3046\u3061\u3001108\u500b\u306e\u7570\u306a\u308b\u30c9\u30e1\u30a4\u30f3\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\u30682\u3064\u306e\u6a5f\u80fd\u7684\u306b\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 CBM6-CBM35-CBM36_like_2\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u3075\u305f\u3064\u306e\u6a5f\u80fd\u7684\u306b\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u9175\u7d20\u3067\u3042\u308a\u3001\u30ec\u30af\u30c1\u30f3\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002 \u3072\u3068\u3064\u306f\u30d0\u30c1\u30eb\u30b9\u83cc\u304b\u3089\u5206\u96e2\u3055\u308c\u305f\u30ad\u30b5\u30f3\u30bf\u30f3\u30ea\u30a2\u30fc\u30bc\u3067\u3042\u308a\u3001\u3082\u3046\u3072\u3068\u3064\u306f\u3001\u30ad\u30a4\u30ed\u30bf\u30de\u30db\u30b3\u30ea\u30ab\u30d3\u304b\u3089\u5206\u96e2\u3055\u308c\u305f\u30b4\u30eb\u30b8\u8f38\u9001\u9175\u7d20\uff08\u30b4\u30eb\u30d9\u30b7\u30f3\uff09\u3067\u3057\u305f\u3002 SWISS-MODEL\u306b\u3088\u308bCbeg4\u304a\u3088\u3073Cbeg5\u30bf\u30f3\u30d1\u30af\u8cea\u914d\u5217\u306e\u5206\u6790\u306f\u3001Cbeg4\u304a\u3088\u3073Cbeg5\u304c\u5358\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 Cbeg4\u304a\u3088\u3073Cbeg5\u306e\u30c9\u30e1\u30a4\u30f3\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\u306f\u3001\u5171\u751f\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u7a2e\u306b\u56fa\u6709\u3067\u3042\u308a\u3001\u6a5f\u80fd\u7684\u306b\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u305f\u65e2\u77e5\u306e\u30ec\u30af\u30c1\u30f3\u3068\u306f\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u672a\u77e5\u306e\u30ec\u30af\u30c1\u30f3\u304c\u7d50\u5408\u3059\u308b\u7cd6\u9396\u306f\u3001\u5171\u901a\u306eGal\u03b21\u20133GlcNac\u03b21\u20132Man\u03b11\u20133Man\u30e2\u30c1\u30fc\u30d5\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002 Glyconnect\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u306f\u3001\u3053\u306eN-\u578b\u7cd6\u9396\u306e\u4e0b\u90e8\u69cb\u9020\u306f\u3001\u672b\u68a2\u8840\u5358\u6838\u7d30\u80de\uff08PBMC\uff09\u304b\u3089\u751f\u6210\u3055\u308c\u305f\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3067\u6700\u3082\u983b\u7e41\u306b\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001Cbeg4\u304a\u3088\u3073Cbeg5\u306f\u3001\u767d\u8840\u7403\u95a2\u9023\u306eN-\u578b\u7cd6\u9396\u69cb\u9020\u306b\u7d50\u5408\u3059\u308b\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002<\/p>\n<p>\u5b9f\u969b\u3001CD14<sup>+<\/sup>\u5358\u7403\u3001CD16<sup>+<\/sup>\u5358\u7403\u3001\u304a\u3088\u3073cDC2\u6a39\u72b6\u7d30\u80de\u306e\u5834\u5408\u3001Cbeg5\u306fIL-1\u03b2\u3001IL-6\u3001IL-8\u3001IL-10\u3001\u304a\u3088\u3073TNF\u03b1\u3092\u30c9\u30fc\u30ba\u4f9d\u5b58\u7684\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002 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of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA\u3089\u306e<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%83%92%e3%83%88%e3%81%a8%e5%85%b1%e7%94%9f%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b%e8%85%b8%e5%86%85%e7%b4%b0%e8%8f%8c%e3%81%8c%e6%8c%81%e3%81%a4%e6%a9%9f%e8%83%bd%e3%81%8c%e3%81%be%e3%81%a0%e8%89%af\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-8928","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8928"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8928\/revisions"}],"predecessor-version":[{"id":8953,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8928\/revisions\/8953"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}