{"id":8874,"date":"2022-05-26T05:52:14","date_gmt":"2022-05-25T20:52:14","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8874"},"modified":"2022-05-26T05:58:26","modified_gmt":"2022-05-25T20:58:26","slug":"roles-of-psgl-1-on-hiv-infection","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/roles-of-psgl-1-on-hiv-infection\/","title":{"rendered":"Roles of PSGL-1 on HIV infection"},"content":{"rendered":"

A group from Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON Canada, etc. has reported that P-selectin glycoprotein ligand-1 (PSGL-1\/CD162) is expressed on HIV-1 envelops and can mediate virus capture and subsequent transfer to permissive cells (CD4+<\/sup> T-cells etc).
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9123692\/<\/a><\/p>\n

P-selectin glycoprotein ligand-1 (PSGL-1\/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P-selectin. Structurally, PSGL-1 is a highly glycosylated homodimeric transmembrane protein, with an extracellular domain (ECD) of 50\u201360 nm in length that extends far out from the cellular surface.<\/p>\n

In reality, PSGL-1 plays diverse roles in the physiology of HIV-1 infection. It has been shown that the viruses with high levels of PSGL-1 are not infectious as show below.<\/p>\n

\"\"<\/a><\/p>\n

Since the primary target of HIV-1 infection, CD4+<\/sup>\u2009T cells, are often found on activated endothelial tissues which display P-selectin in inflammatory conditions, it was interested in testing whether virions captured by P-selectin could be transferred to nearby permissive cells to elicit infection.
\nIt was decided to test this model with T cell line and PBMC viruses, which contained lower levels of PSGL-1 and higher levels of gp120. We observed that viruses produced in T cell lines and primary PBMC were captured by P-selectin at levels that were markedly higher than the control. Most importantly, both viruses were effectively captured by P-selectin and transferred to HIV-1-permissive cells, suggesting that this mechanism of PSGL-1-mediated virus capture and transfer might also occur when HIV viruses encounter P-selectin on cell surfaces in vivo.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toront<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8874","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8874"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8874\/revisions"}],"predecessor-version":[{"id":8879,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8874\/revisions\/8879"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}