{"id":8865,"date":"2022-05-26T05:52:14","date_gmt":"2022-05-25T20:52:14","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8865"},"modified":"2022-05-26T05:57:09","modified_gmt":"2022-05-25T20:57:09","slug":"hiv%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bpsgl-1%e3%81%ae%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/hiv%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bpsgl-1%e3%81%ae%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/","title":{"rendered":"HIV\u611f\u67d3\u306b\u304a\u3051\u308bPSGL-1\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON Canada\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001P-\u30bb\u30ec\u30af\u30c1\u30f3\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30ac\u30f3\u30c9-1 (PSGL-1\/CD162) \u304cHIV-1\u306e\u30a6\u30a4\u30eb\u30b9\u30a8\u30f3\u30d9\u30ed\u30fc\u30d7\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u30a6\u30a4\u30eb\u30b9\u306e\u6355\u7372\u3068\u3001\u611f\u67d3\u7d30\u80de (CD4<sup>+<\/sup> T-\u7d30\u80de\u306a\u3069)\u3078\u306e\u30c8\u30e9\u30f3\u30b9\u30d5\u30a1\u30fc\u3092\u5a92\u4ecb\u3057\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9123692\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9123692\/<\/a><\/p>\n<p>P-\u30bb\u30ec\u30af\u30c1\u30f3\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30ac\u30f3\u30c9-1\uff08PSGL-1\/CD162\uff09\u306f\u3001\u305d\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308bP-\u30bb\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u4ecb\u3057\u3066\u767d\u8840\u7403\u306e\u30ed\u30fc\u30ea\u30f3\u30b0\u3092\u5236\u5fa1\u3059\u308b\u5f79\u5272\u306b\u3064\u3044\u3066\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u69cb\u9020\u7684\u306b\u306f\u3001PSGL-1\u306f\u9ad8\u5ea6\u306b\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u305f\u30db\u30e2\u4e8c\u91cf\u4f53\u819c\u8cab\u901a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\uff08ECD\uff09\u306e\u9577\u3055\u304c50\u301c60 nm\u3067\u3001\u7d30\u80de\u8868\u9762\u304b\u3089\u7a81\u304d\u51fa\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5b9f\u969b\u306b\u3001PSGL-1\u306fHIV-1\u611f\u67d3\u306e\u751f\u7406\u5b66\u306b\u304a\u3044\u3066\u3055\u307e\u3056\u307e\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u793a\u3059\u3088\u3046\u306b\u3001PSGL-1\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u30a6\u30a4\u30eb\u30b9\u306f\u975e\u611f\u67d3\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/PSGL-1High_HIV.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8867\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/PSGL-1High_HIV-300x184.png\" alt=\"\" width=\"300\" height=\"184\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/PSGL-1High_HIV-300x184.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/PSGL-1High_HIV.png 493w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>HIV-1\u611f\u67d3\u306e\u4e3b\u306a\u6a19\u7684\u3067\u3042\u308bCD4<sup>+<\/sup> T-\u7d30\u80de\u306f\u3001\u708e\u75c7\u72b6\u614b\u3067P-\u30bb\u30ec\u30af\u30c1\u30f3\u3092\u767a\u73fe\u3059\u308b\u6d3b\u6027\u5316\u3057\u305f\u5185\u76ae\u7d44\u7e54\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u305f\u3081\u3001P-\u30bb\u30ec\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u6355\u6349\u3055\u308c\u308bPSGL-1\u3092\u767a\u73fe\u3059\u308b\u30a6\u30a4\u30eb\u30b9\u304c\u8fd1\u304f\u306e\u611f\u67d3\u6a19\u7684\u7d30\u80de\u306b\u79fb\u52d5\u3057\u3001\u611f\u67d3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u30e2\u30c7\u30eb\u3092\u3001\u4f4e\u30ec\u30d9\u30eb\u306ePSGL-1\u3068\u9ad8\u30ec\u30d9\u30eb\u306egp120\u3092\u767a\u73fe\u3059\u308bT-\u7d30\u80de\u611f\u67d3\u30a6\u30a4\u30eb\u30b9\u3068PBMC\u611f\u67d3\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u3066\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002T-\u7d30\u80de\u304a\u3088\u3073PBMC\u3067\u7523\u751f\u3055\u308c\u305f\u30a6\u30a4\u30eb\u30b9\u304c\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3088\u308a\u3082\u8457\u3057\u304f\u9ad8\u3044\u30ec\u30d9\u30eb\u3067P-\u30bb\u30ec\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u6355\u6349\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u4e21\u65b9\u306e\u30a6\u30a4\u30eb\u30b9\u304cP-\u30bb\u30ec\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u52b9\u679c\u7684\u306b\u6355\u6349\u3055\u308c\u3001HIV-1\u306e\u611f\u67d3\u6a19\u7684\u7d30\u80de\u306b\u30c8\u30e9\u30f3\u30b9\u30d5\u30a1\u30fc\u3055\u308c\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u3001HIV\u30a6\u30a4\u30eb\u30b9\u304cin vivo\u3067P-\u30bb\u30ec\u30af\u30c1\u30f3\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306b\u906d\u9047\u3057\u305f\u6642\u3001PSGL-1\u3092\u4ecb\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u306e\u6355\u6349\u3068\u30c8\u30e9\u30f3\u30b9\u30d5\u30a1\u30fc\u3068\u3044\u3046\u611f\u67d3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/HIV-Infectivity_P-Selectin.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8868\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/HIV-Infectivity_P-Selectin-300x137.png\" alt=\"\" width=\"300\" height=\"137\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/HIV-Infectivity_P-Selectin-300x137.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/HIV-Infectivity_P-Selectin-600x274.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/HIV-Infectivity_P-Selectin.png 662w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON Canada\u3089<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/hiv%e6%84%9f%e6%9f%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bpsgl-1%e3%81%ae%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-8865","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8865"}],"version-history":[{"count":9,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8865\/revisions"}],"predecessor-version":[{"id":8878,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8865\/revisions\/8878"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}