{"id":8789,"date":"2022-05-14T10:09:35","date_gmt":"2022-05-14T01:09:35","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8789"},"modified":"2022-05-15T14:44:08","modified_gmt":"2022-05-15T05:44:08","slug":"%e5%a4%9a%e4%be%a19-o-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e5%8c%96%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e4%bf%ae%e9%a3%be%e3%82%92%e6%8c%81%e3%81%a4%e7%b3%96%e9%8e%96%e3%82%af%e3%83%a9%e3%82%b9","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e5%a4%9a%e4%be%a19-o-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e5%8c%96%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e4%bf%ae%e9%a3%be%e3%82%92%e6%8c%81%e3%81%a4%e7%b3%96%e9%8e%96%e3%82%af%e3%83%a9%e3%82%b9\/","title":{"rendered":"\u591a\u4fa19-O-\u30a2\u30bb\u30c1\u30eb\u5316\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u3092\u6301\u3064\u7cd6\u9396\u30af\u30e9\u30b9\u30bf\u30fc\u3092SARS-CoV-2\u306e\u963b\u5bb3\u5264\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b"},"content":{"rendered":"<p>Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 catholique de Louvain, Louvain-la-Neuve, Belgium\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u591a\u4fa19-O-\u30a2\u30bb\u30c1\u30eb\u5316-\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u3092\u6301\u3064\u7cd6\u9396\u30af\u30e9\u30b9\u30bf\u30fc\u304c\u3001SARS-CoV-2\u611f\u67d3\u306e\u5f37\u529b\u306a\u963b\u5bb3\u5264\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-30313-8\">https:\/\/www.nature.com\/articles\/s41467-022-30313-8<\/a><\/p>\n<p>SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306f\u3001\u7cd6\u9396\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\uff08GBD\uff09\u3092\u542b\u3080N\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\uff08NTD\uff09\u3068\u3001\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\uff08RBD\uff09\u3092\u542b\u3080C\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\uff08CTD\uff09\u306b\u5206\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002GBD\u306f\u3001\u307b\u3068\u3093\u3069\u306eCoV\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7cd6\u8102\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u304c\u3001RBD\u306fSARS-CoV-2\u306e\u5834\u5408\u3001ACE2\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u307e\u3059\u3002<\/p>\n<p>\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9OC43\u3068HKU\u304cSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4fdd\u5b58\u3055\u308c\u305f\u53d7\u5bb9\u4f53\u7d50\u5408\u90e8\u4f4d\u3092\u4ecb\u3057\u30669-O-\u30a2\u30bb\u30c1\u30eb\u5316\u30b7\u30a2\u30eb\u9178\uff089-AcSA\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u8457\u8005\u3089\u306f\u3001\u7279\u306b\u8208\u5473\u6df1\u3044\u7cd6\u9396\u3068\u3057\u30669-AcSA\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3057\u305f\u3002<\/p>\n<p>\u4e00\u4fa1\u306e9-AcSA\u306f\u9ad8\u3044IC<sub>50<\/sub> 100 \u00b5M\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u3059\u3079\u3066\u306e9-AcSA\u7531\u6765\u306e\u7cd6\u9396\u30af\u30e9\u30b9\u30bf\u30fc\u306f\u3001\u305d\u306e\u591a\u4fa1\u52b9\u679c\u306b\u3088\u3063\u3066\u30011\u301c10 \u00b5M\u306eIC<sub>50<\/sub>\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u4e2d\u3067\u3082\u30019-AcSA-\u30dd\u30eb\u30d5\u30a3\u30ea\u30f3\u306f\u3001\u7cbe\u88fd\u3055\u308c\u305f9-AcSA\u3068\u7d30\u80de\u30a2\u30c3\u30bb\u30a4\u306e\u4e21\u65b9\u3067\u3001sub-\u00b5M\u7bc4\u56f2\u306eIC<sub>50<\/sub>\u3092\u793a\u3057\u3001\u6cbb\u7642\u85ac\u3068\u3057\u3066\u512a\u308c\u305f\u5019\u88dc\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/9-AcSC-oligomers_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/9-AcSC-oligomers_SARS-CoV-2-300x186.png\" alt=\"\" width=\"300\" height=\"186\" class=\"alignnone size-medium wp-image-8791\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/9-AcSC-oligomers_SARS-CoV-2-300x186.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/9-AcSC-oligomers_SARS-CoV-2-600x373.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/05\/9-AcSC-oligomers_SARS-CoV-2.png 713w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 catholique de Louvain, Louvain-la-Neuve, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e5%a4%9a%e4%be%a19-o-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e5%8c%96%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e4%bf%ae%e9%a3%be%e3%82%92%e6%8c%81%e3%81%a4%e7%b3%96%e9%8e%96%e3%82%af%e3%83%a9%e3%82%b9\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24,42],"tags":[],"class_list":["post-8789","post","type-post","status-publish","format-standard","hentry","category-history-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Louvain Institute of Biomolecular Science and Technolog\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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