{"id":8638,"date":"2022-04-22T14:38:22","date_gmt":"2022-04-22T05:38:22","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8638"},"modified":"2022-04-22T16:36:33","modified_gmt":"2022-04-22T07:36:33","slug":"sars-cov-2-omicron%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e3%80%81%e4%bd%95%e6%95%85%e3%80%81%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%9335b5%e3%81%af%e9%ab%98%e3%81%84%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2-omicron%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e3%80%81%e4%bd%95%e6%95%85%e3%80%81%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%9335b5%e3%81%af%e9%ab%98%e3%81%84%e4%b8%ad\/","title":{"rendered":"SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u3001\u4f55\u6545\u3001\u4e2d\u548c\u6297\u4f5335B5\u306f\u9ad8\u3044\u4e2d\u548c\u80fd\u529b\u3092\u793a\u3059\u306e\u304b\uff1f"},"content":{"rendered":"<p>Department of Gastroenterology of the Second Affiliated Hospital, School of Medicine and Life Sciences Institute, Zhejiang University, Hangzhou, China\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e2d\u548c\u6297\u4f5335B5\u306f\u3001RBD\u306e\u300c\u30c0\u30a6\u30f3\u300d\u72b6\u614b\u304b\u3089\u300c\u30a2\u30c3\u30d7\u300d\u72b6\u614b\u3078\u306e\u9077\u79fb\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u5bbf\u4e3b\u4fb5\u5165\u53d7\u5bb9\u4f53ACE2\u306e\u8a8d\u8b58\u3092\u53ef\u80fd\u3068\u3059\u308b\u4fdd\u5b58\u3055\u308c\u305f<strong>N-\u578b\u7cd6\u9396\u30b9\u30a4\u30c3\u30c1<\/strong>\u69cb\u9020\u5185\u306b\u6709\u610f\u306a\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306b\u3088\u308a\u3001SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u5909\u7570\u4f53\u3092\u5f37\u529b\u306b\u4e2d\u548c\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u3001\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8960183\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8960183\/<\/a><\/p>\n<p>\u6297\u4f53\u306b\u3088\u308bSARS-CoV-2\u306e\u4e2d\u548c\u306f\u3001<strong>ACE2\u7af6\u5408<\/strong>\u3001<strong>ACE2\u5206\u5b50\u6a21\u5023<\/strong>\u3001<strong>Fc\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u4e2d\u548c<\/strong>\u306a\u3069\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002 N-\u578b\u7cd6\u9396\u4fee\u98fe\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u3068\u5b89\u5b9a\u6027\u306e\u5236\u5fa1\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u7d50\u5408\u65b9\u5411\u6027\u306a\u3069\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u75c5\u7406\u5b66\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u7cd6\u9396\u4fee\u98fe\u306f\u7279\u5b9a\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u3092\u30b7\u30fc\u30eb\u30c9\u3057\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u514d\u75ab\u56de\u907f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7cd6\u9396\u306e\u30b7\u30fc\u30eb\u30c9\u6a5f\u80fd\u306f\u305d\u308c\u3068\u3057\u3066\u3001SARS-CoV-2\u306eN\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\uff08NTD\uff09\u5185\u306e<strong>N165<\/strong>\u304a\u3088\u3073<strong>N234<\/strong>\u306b\u5b58\u5728\u3059\u308b\u7cd6\u9396\u306f<strong>\u5206\u5b50\u30b9\u30a4\u30c3\u30c1<\/strong>\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u53d7\u5bb9\u4f53\u304cACE2\u306b\u7d50\u5408\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u300c\u30c0\u30a6\u30f3\u300d\u72b6\u614b\u304b\u3089\u300c\u30a2\u30c3\u30d7\u300d\u72b6\u614b\u3078\u306eRBD\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u9077\u79fb\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002 N165\u3068N234\u306fSARS-CoV-1\u3068MERS-CoV\u3067\u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eRBD\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u8ee2\u79fb\u306e\u4e00\u822c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30aa\u30df\u30af\u30ed\u30f3\u306eSpike\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u3001\u9855\u8457\u306a\u6297\u539f\u6027\u306e\u30b7\u30d5\u30c8\u3068\u69cb\u9020\u5909\u5316\u304c\u3042\u308a\u3001\u307b\u3068\u3093\u3069\u306e\u4e2d\u548c\u6297\u4f53\u304b\u3089\u30aa\u30df\u30af\u30ed\u30f3\u5909\u7570\u4f53\u306f\u514d\u75ab\u56de\u907f\u3092\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u904e\u53bb\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u4e2d\u548c\u6297\u4f5335B5\u304cWT\u304a\u3088\u3073SARS-CoV-2\u306e\u30d9\u30fc\u30bf\u304a\u3088\u3073\u30c7\u30eb\u30bf\u5909\u7570\u4f53\u306b\u5bfe\u3057\u3066\u4e2d\u548c\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002 <strong>35B5\u306fSpike\u4e09\u91cf\u4f53\u3092\u5206\u96e2\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u3067\u3001SARS-CoV-2\u3092\u4e2d\u548c\u3057\u307e\u3059<\/strong>\u3002\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u4e2d\u548c\u6297\u4f5335B5\u304c\u4ed6\u306e\u591a\u304f\u306e\u4e2d\u548c\u6297\u4f53\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u9ad8\u3044\u4e2d\u548c\u52b9\u679c\u3067\u30aa\u30df\u30af\u30ed\u30f3\u5909\u7570\u4f53\u3092\u4e2d\u548c\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nSpike\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u89e3\u96e2\u3059\u308b\u5b9f\u969b\u306e\u7406\u7531\u306f\u300135B5\u304c\u4fdd\u5b58\u3055\u308c\u305fRBD\u306e\u7cd6\u9396\u30b9\u30a4\u30c3\u30c1\u3092\u5909\u4f4d\u3055\u305b\u3001RBD\u306e\u30a2\u30c3\u30d7\u72b6\u614b\u3092\u4e0d\u5b89\u5b9a\u5316\u3055\u305b\u3001\u6700\u7d42\u7684\u306bSpike\u4e09\u91cf\u4f53\u304b\u3089\u306eS1\u306e\u306f\u304c\u308c\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u3067\u3059\u300235B5\u306e\u7cd6\u9396\u5909\u4f4d\u4f5c\u7528\u306f\u3001SARS-CoV-2\u306b\u5bfe\u3059\u308b\u4e2d\u548c\u6297\u4f53\u306e\u524d\u4f8b\u306e\u306a\u3044\u4e2d\u548c\u4f5c\u7528\u3092\u8868\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u3001\u901a\u5e38\u306eACE2\u7af6\u5408\u304a\u3088\u3073ACE2\u5206\u5b50\u6a21\u5023\u3001\u304a\u3088\u3073Fc\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u4e2d\u548c\u30e1\u30ab\u30cb\u30ba\u30e0\u3089\u3068\u306f\u6839\u672c\u7684\u306b\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/35B5_Spike-trimer-dissociation.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8642\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/35B5_Spike-trimer-dissociation-300x170.png\" alt=\"\" width=\"300\" height=\"170\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/35B5_Spike-trimer-dissociation-300x170.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/35B5_Spike-trimer-dissociation-600x339.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/35B5_Spike-trimer-dissociation.png 757w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>\u3000\u3053\u306e\u56f3\u306f\u3001in vitro \u3067\u306e35B5\u3068SARS-CoV-2 \u30aa\u30df\u30af\u30ed\u30f3\u306e\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u3067\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306eSpike\u4e09\u91cf\u4f53\u304c\u5b8c\u5168\u306b\u5206\u96e2\u3055\u308c\u3066\u3057\u307e\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Gastroenterology of the Second Affiliated Hospital, School of Medicine and Life Sciences Institu<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2-omicron%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e3%80%81%e4%bd%95%e6%95%85%e3%80%81%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%9335b5%e3%81%af%e9%ab%98%e3%81%84%e4%b8%ad\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-8638","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Department of Gastroenterology of the Second Affiliated\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2-omicron%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e3%80%81%e4%bd%95%e6%95%85%e3%80%81%e4%b8%ad%e5%92%8c%e6%8a%97%e4%bd%9335b5%e3%81%af%e9%ab%98%e3%81%84%e4%b8%ad\/\" \/>\n\t<meta name=\"generator\" 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