{"id":8535,"date":"2022-04-10T07:58:59","date_gmt":"2022-04-09T22:58:59","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8535"},"modified":"2022-04-10T08:06:34","modified_gmt":"2022-04-09T23:06:34","slug":"gal-9-enhanced-sars-cov-2-infection-and-replication","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/gal-9-enhanced-sars-cov-2-infection-and-replication\/","title":{"rendered":"Gal-9 enhances SARS-CoV-2 replication and inflammation"},"content":{"rendered":"<p>A group from Department of Laboratory Medicine, University of California, San Francisco, CA, USA. etc. has reported that Gal-9 enhanced SARS-CoV-2 infection.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35378763\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35378763\/<\/a><\/p>\n<p>It was found that Gal-9 enhances SARS-CoV-2 replication in human airway epithelial cells (AECs), mediated by facilitating cellular entry in an ACE2-dependent manner, by enhancing the attachment of SARS-CoV-2 virions to the cell surface by bridging the pathogen surface and receptors on host tissues in a glycosylation-dependent manner.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/Gal-9_enhances_SARS-CoV-2_infection.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-8531\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/Gal-9_enhances_SARS-CoV-2_infection-282x300.png\" alt=\"\" width=\"282\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/Gal-9_enhances_SARS-CoV-2_infection-282x300.png 282w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/Gal-9_enhances_SARS-CoV-2_infection.png 369w\" sizes=\"auto, (max-width: 282px) 100vw, 282px\" \/><\/a><\/p>\n<p>Clinically speaking, small molecules and anti-Gal-9 monoclonal antibodies (e.g. LYT-200) that antagonize Gal-9 activity may have utility in COVID-19.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Laboratory Medicine, University of California, San Francisco, CA, USA. etc. has rep<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/gal-9-enhanced-sars-cov-2-infection-and-replication\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-8535","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8535"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8535\/revisions"}],"predecessor-version":[{"id":8542,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8535\/revisions\/8542"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}