{"id":8494,"date":"2022-04-09T10:43:09","date_gmt":"2022-04-09T01:43:09","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8494"},"modified":"2022-04-09T12:08:31","modified_gmt":"2022-04-09T03:08:31","slug":"ace2%e9%9d%9e%e4%be%9d%e5%ad%98%e3%81%a7%e3%80%81sars-cov-2%e3%81%8c%e3%83%9e%e3%82%af%e3%83%ad%e3%83%95%e3%82%a1%e3%83%bc%e3%82%b8%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%99%e3%82%8b%ef%bc%9acd169-siglec-1","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/ace2%e9%9d%9e%e4%be%9d%e5%ad%98%e3%81%a7%e3%80%81sars-cov-2%e3%81%8c%e3%83%9e%e3%82%af%e3%83%ad%e3%83%95%e3%82%a1%e3%83%bc%e3%82%b8%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%99%e3%82%8b%ef%bc%9acd169-siglec-1\/","title":{"rendered":"ACE2\u975e\u4f9d\u5b58\u3067\u3001SARS-CoV-2\u304c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u611f\u67d3\u3059\u308b\uff1aCD169\/Siglec-1\uff08I-\u578b\u30ec\u30af\u30c1\u30f3\uff09\u3092\u5a92\u4ecb\u3059\u308bSARS-CoV-2\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306e\u76f4\u63a5\u611f\u67d3\u6a5f\u69cb"},"content":{"rendered":"<p>Department of Microbiology, Boston University School of Medicine, Boston, MA, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001<strong>CD169\/Siglec-1\u3001\u9aa8\u9ac4\u7d30\u80de\u7279\u7570\u7684\u306aI-\u578b\u30ec\u30af\u30c1\u30f3<\/strong>\u3001\u304c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306eSARS-CoV-2\u306eACE2\u975e\u4f9d\u5b58\u6027\u306e\u611f\u67d3\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35378756\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35378756\/<\/a><\/p>\n<p>\u8840\u4e2d\u3092\u5de1\u56de\u3059\u308b\u5358\u7403\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u304a\u3088\u3073\u7d44\u7e54\u306b\u5b58\u5728\u3059\u308b\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3089\u306f\u3001SARS-CoV-2\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u3067\u3042\u308bACE2\u3092\u57fa\u672c\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u306b\u306f\u3001\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u4f4e\u30ec\u30d9\u30eb\u306eTMPRSS2\u3001\u304a\u3088\u3073\u4e2d\u30ec\u30d9\u30eb\u306e\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u30ab\u30c6\u30d7\u30b7\u30f3\u3089\u306eSARS-CoV-2\u611f\u67d3\u306b\u5fc5\u8981\u306a\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u304c\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001CD169\/Siglec-1\uff08I-\u578b\u30ec\u30af\u30c1\u30f3\uff09\u306f\u3001\u813e\u81d3\u306e\u8d64\u813e\u9ac4\u3001\u6ffe\u80de\u5468\u56f2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u88ab\u819c\u4e0b\u6d1e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u9ad8\u5ea6\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3057\u3001CD169\u306e\u767a\u73fe\u306f\u3001\u7279\u306bI\u578b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff08IFN\uff09\u306b\u5fdc\u7b54\u3057\u3066\u3001\u708e\u75c7\u6027\u6761\u4ef6\u4e0b\u3067\u672b\u68a2\u8840\u5358\u7403\u3067\u767a\u73fe\u6602\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u9aa8\u9ac4\u7d30\u80de\u7279\u7570\u7684\u53d7\u5bb9\u4f53CD169\/Siglec-1\u3092\u767a\u73fe\u3059\u308b2\u3064\u306e\u7570\u306a\u308b\u30d2\u30c8\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30e2\u30c7\u30eb\u3001PMA\u5206\u5316THP1\u7d30\u80de\uff08THP1\/PMA\uff09\u3068\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08MDM\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001ACE2\u306e\u5b58\u5728\u4e0b\u307e\u305f\u306f\u975e\u5b58\u5728\u4e0b\u3067\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304cSARS-CoV-2\u611f\u67d3\u306e\u708e\u75c7\u8a98\u767a\u306b\u95a2\u308f\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>SARS-CoV-2 Spike NTD\u3092\u6a19\u7684\u3068\u3059\u308b\u6297\u4f53\u306b\u3088\u308b\u524d\u51e6\u7406\u3084\u3001E64D\u306b\u3088\u308b\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u30ab\u30c6\u30d7\u30b7\u30f3\u306e\u963b\u5bb3\u306f\u3001CD169<sup>+<\/sup>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308bSARS-CoV-2 Spike\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u306e\u611f\u67d3\u3092\u8457\u3057\u304f\u5f31\u3081\u307e\u3057\u305f\u304c\u3001TMPRSS2\u963b\u5bb3\u5264\uff08\u30ab\u30e2\u30b9\u30bf\u30c3\u30c8\uff09\u306f\u5168\u304f\u52b9\u679c\u304c\u306a\u304f\u3001SARS-CoV-2 Spike \u304c\u3001ACE2\u6b20\u640d\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08MDM\uff09\u306b\u5bfe\u3057\u3066\u3001<strong>\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u3092\u4ecb\u3057\u3066\u611f\u67d3\u3057\u3066\u3044\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001CD169\u3092\u767a\u73fe\u3059\u308bTHP1\u7d30\u80de\u306f\u3001THP1\/ACE2\u7d30\u80de\u3067\u89b3\u5bdf\u3055\u308c\u305f\u30ec\u30d9\u30eb\u306b\u5339\u6575\u3059\u308bSARS-CoV-2 Spike\u306e\u7d50\u5408\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001CD169\u3092\u767a\u73fe\u3059\u308bTHP1\/PMA\u7d30\u80de\u306f\u3001SARS-CoV-2\u611f\u67d3\u5f8c\u3001\u4f4e\u30ec\u30d9\u30eb\u306e\u30a6\u30a4\u30eb\u30b9dsRNA\u7523\u751f\u3057\u304b\u793a\u3055\u305a\u3001\u611f\u67d3\u306e\u904e\u7a0b\u3067\u3082\u305d\u308c\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u3001IL-6\u3001TNF\u03b1\u3001IL-1\u03b2\u3001\u304a\u3088\u3073IL-18\u306e\u7523\u751f\u306f\u3001\u611f\u67d3\u3057\u305fCD169<sup>+<\/sup> THP1\/PMA\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u6709\u610f\u306b\u4e0a\u6607\u3057\u3001\u521d\u671f\u306e\u30a6\u30a4\u30eb\u30b9RNA\u306e\u7523\u751f\u304c\u81ea\u7136\u514d\u75ab\u6d3b\u6027\u5316\u306e\u91cd\u8981\u306a\u30c8\u30ea\u30ac\u30fc\u3068\u306a\u308b\u3053\u3068\u5206\u304b\u308a\u307e\u3059\u3001\u8a00\u3044\u63db\u3048\u308c\u3070\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306eSARS-CoV-2\u306e\u611f\u67d3\u304c\u708e\u75c7\u8a98\u767a\u6027\u53cd\u5fdc\u3092\u8a98\u767a\u3057\u3001\u6700\u7d42\u7684\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Microbiology, Boston University School of Medicine, Boston, MA, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001CD169\/Siglec-1\u3001\u9aa8\u9ac4\u7d30\u80de\u7279\u7570<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/ace2%e9%9d%9e%e4%be%9d%e5%ad%98%e3%81%a7%e3%80%81sars-cov-2%e3%81%8c%e3%83%9e%e3%82%af%e3%83%ad%e3%83%95%e3%82%a1%e3%83%bc%e3%82%b8%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%99%e3%82%8b%ef%bc%9acd169-siglec-1\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-8494","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Department of Microbiology, Boston University School of\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" 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