{"id":8460,"date":"2022-04-05T12:40:11","date_gmt":"2022-04-05T03:40:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8460"},"modified":"2022-04-05T12:42:02","modified_gmt":"2022-04-05T03:42:02","slug":"urine-galectin-3-binding-protein-ug3bp-is-a-potential-biomarker-of-lupus-nephritis-ln","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/urine-galectin-3-binding-protein-ug3bp-is-a-potential-biomarker-of-lupus-nephritis-ln\/","title":{"rendered":"urine Galectin-3 binding protein (uG3BP) is a potential biomarker of Lupus nephritis (LN)"},"content":{"rendered":"<p>A group from Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University School of Medicine, China, etc. has reported that urine Galectin-3 binding protein (uG3BP) is a potential biomarker of Lupus nephritis (LN).<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8962213\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8962213\/<\/a><\/p>\n<p>The levels of uG3BP were significantly increased in active LN patients compared to those in inactive LN (p<0.001), CKD patients (p=0.01), and healthy controls (p<0.001). ROC analysis indicated a good discrimination ability of uG3BP to differentiate active LN from chronic kidney diseases (CKD) patients (AUC=0.7), inactive LN (AUC=0.76), or healthy controls (AUC=0.87).\n\nThe uG3BP levels were measured in urine samples by ELISA assay using human Galectin-3BP\/MAC-2BP ELISA kit (DY2226) from R&#038;D Systems (Minneapolis, MN, USA) according to the manufacturer\u2019s instructions. All urine samples were diluted 1:30. uG3BP levels were normalized by urine creatinine levels. Urine creatinine levels were measured by Creatinine Parameter Assay Kit (KGE005, R&#038;D Systems, Minneapolis, MN) using the same samples.\n\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/uG3BP.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/uG3BP-300x294.png\" alt=\"\" width=\"300\" height=\"294\" class=\"alignnone size-medium wp-image-8453\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/uG3BP-300x294.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/04\/uG3BP.png 373w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, School of Medicin<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/urine-galectin-3-binding-protein-ug3bp-is-a-potential-biomarker-of-lupus-nephritis-ln\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-8460","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8460"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8460\/revisions"}],"predecessor-version":[{"id":8461,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8460\/revisions\/8461"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}