{"id":8393,"date":"2022-03-24T14:39:59","date_gmt":"2022-03-24T05:39:59","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=8393"},"modified":"2022-03-24T15:28:46","modified_gmt":"2022-03-24T06:28:46","slug":"targeting-tgf-%ce%b21-pathway-might-be-a-promising-approach-to-enhance-immune-checkpoint-blockade-pd-1-pd-l1-in-nasopharyngeal-carcinoma","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/targeting-tgf-%ce%b21-pathway-might-be-a-promising-approach-to-enhance-immune-checkpoint-blockade-pd-1-pd-l1-in-nasopharyngeal-carcinoma\/","title":{"rendered":"Targeting TGF-\u03b21 pathway might be a promising approach to enhance immune checkpoint blockade PD-1\/PD-L1 in nasopharyngeal carcinoma"},"content":{"rendered":"<p>A group from Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, etc. has reported that targeting TGF-\u03b21 pathway might be a promising approach to enhance immune checkpoint blockade PD-1\/PD-L1 in nasopharyngeal carcinoma (NPC).<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35311117\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35311117\/<\/a><\/p>\n<p>It is well known that PD-L1, programmed death ligand-1, is a transmembrane glycoprotein expressed by tumor cells and PD-L1 inhibits T cells activity and promotes immune evasion through binding to its receptor PD-1 on T cells.<\/p>\n<p>TGF-\u03b2 is a multifunctional cytokine with an important role in both physiologic and pathologic processes, including cancer. The aberrantly upregulated production of TGF-\u03b2 has been strongly implicated in tumor progression, angiogenesis, and metastasis, as well as immune escape. TGF-\u03b2 has been regarded as a critical immunosuppressive cytokine, which suppresses the antitumor activity of effector cells, including CD8<sup>+<\/sup> T cells, natural killer (NK) cells, and macrophages.<\/p>\n<p>In this study, it was confirmed that PD-L1 was heavily glycosylated in NPC, and found that TGF-\u03b21 played an important role in N-glycosylation of PD-L1.<br \/>\nInhibition of TGF-\u03b21 by a TGF-\u03b2 type I receptor inhibitor (SB431542) reduced not only PD-L1 expression but also PD-L1 glycosylation. The reduction of PD-L1 glycosylation was confirmed by loss of PD-L1 binding ability to ConA lectin. <\/p>\n<p>Authors found that the glycosylation of PD-L1 was affected by TGF-\u03b21 through c-Jun\/STT3A signaling pathway, suggesting that targeting TGF-\u03b21 pathway might be a promising approach to enhance immune checkpoint blockade in NPC avoiding deglycosylatin of PD-L1.<\/p>\n<p><a href=\"\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-300x264.png\" alt=\"\" width=\"300\" height=\"264\" class=\"alignnone size-medium wp-image-8383\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-300x264.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1-600x528.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/03\/deglycosylation-of-PD-L1.png 629w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> Co-culture of NPC cells (5-8F cells) and Jurkat T cells, conducted with STT3A-knockdown (shSTT3Acells), SB431542 and tunicamycin (TM) pretreatments on T cells. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/targeting-tgf-%ce%b21-pathway-might-be-a-promising-approach-to-enhance-immune-checkpoint-blockade-pd-1-pd-l1-in-nasopharyngeal-carcinoma\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-8393","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=8393"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8393\/revisions"}],"predecessor-version":[{"id":8398,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/8393\/revisions\/8398"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=8393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=8393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=8393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}